Prediction of venous wound healing with laser speckle imaging

Timme M. A. J. van Vuuren; Carina Van Zandvoort; Suat Doganci; Ineke Zwiers; Arina J. tenCate-Hoek; Ralph L. M. Kurstjens; Cees H. A. Wittens

doi:10.1177/0268355517718760

Prediction of venous wound healing with laser speckle imaging

Timme M. A. J. van Vuuren^*, Carina Van Zandvoort, Suat Doganci, Ineke Zwiers, Arina J. tenCate-Hoek, Ralph L. M. Kurstjens, Cees H. A. Wittens

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

6 Citations (Web of Science)

Abstract

Introduction Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing.

Methods After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated.

Results In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p=0.03).

Conclusion Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.

Original language	English
Pages (from-to)	658-664
Number of pages	7
Journal	Phlebology: The Journal of Venous Disease
Volume	32
Issue number	10
DOIs	https://doi.org/10.1177/0268355517718760
Publication status	Published - Dec 2017

Keywords

Venous ulceration
venous disease
wound care
LEG
PATHOPHYSIOLOGY
OBSTRUCTION

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10.1177/0268355517718760Licence: CC BY-NC

Cite this

@article{a65d0f3cff5a4d0dad30ff710ac72164,

title = "Prediction of venous wound healing with laser speckle imaging",

abstract = "Introduction Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing.Methods After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated.Results In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p=0.03).Conclusion Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.",

keywords = "Venous ulceration, venous disease, wound care, LEG, PATHOPHYSIOLOGY, OBSTRUCTION",

author = "{van Vuuren}, {Timme M. A. J.} and {Van Zandvoort}, Carina and Suat Doganci and Ineke Zwiers and tenCate-Hoek, {Arina J.} and Kurstjens, {Ralph L. M.} and Wittens, {Cees H. A.}",

year = "2017",

month = dec,

doi = "10.1177/0268355517718760",

language = "English",

volume = "32",

pages = "658--664",

journal = "Phlebology: The Journal of Venous Disease",

issn = "0268-3555",

publisher = "SAGE Publications Inc.",

number = "10",

}

TY - JOUR

T1 - Prediction of venous wound healing with laser speckle imaging

AU - van Vuuren, Timme M. A. J.

AU - Van Zandvoort, Carina

AU - Doganci, Suat

AU - Zwiers, Ineke

AU - tenCate-Hoek, Arina J.

AU - Kurstjens, Ralph L. M.

AU - Wittens, Cees H. A.

PY - 2017/12

Y1 - 2017/12

N2 - Introduction Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing.Methods After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated.Results In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p=0.03).Conclusion Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.

AB - Introduction Laser speckle imaging is used for noninvasive assessment of blood flow of cutaneous wounds. The aim of this study was to assess if laser speckle imaging can be used as a predictor of venous ulcer healing.Methods After generating the flux speckle images, three regions of interest (ROI) were identified to measure the flow. Sensitivity, specificity, negative predictive value, and positive predictive value for ulcer healing were calculated.Results In total, 17 limbs were included. A sensitivity of 92.3%, specificity of 75.0%, PPV of 80.0%, and NPV 75.0% were found in predicting wound healing based on laser speckle images. Mean flux values were lowest in the center (ROI I) and showed an increase at the wound edge (ROI II, p=0.03).Conclusion Laser speckle imaging shows acceptable sensitivity and specificity rates in predicting venous ulcer healing. The wound edge proved to be the best probability for the prediction of wound healing.

KW - Venous ulceration

KW - venous disease

KW - wound care

KW - LEG

KW - PATHOPHYSIOLOGY

KW - OBSTRUCTION

U2 - 10.1177/0268355517718760

DO - 10.1177/0268355517718760

M3 - Article

SN - 0268-3555

VL - 32

SP - 658

EP - 664

JO - Phlebology: The Journal of Venous Disease

JF - Phlebology: The Journal of Venous Disease

IS - 10

ER -