TY - JOUR
T1 - Prediction of transition from common adolescent bipolar experiences to bipolar disorder: 10-year study
AU - Tijssen, Marijn J. A.
AU - van Os, Jim
AU - Wittchen, Hans-Ulrich
AU - Lieb, Roselind
AU - Beesdo-Baum, Katja
AU - Mengelers, Ron
AU - Wichers, Marieke
PY - 2010/2
Y1 - 2010/2
N2 - Background Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent. Aims To examine whether the risk of transition to bipolar disorder is conditional on the extent of persistence of subthreshold affective phenotypes. Method In a 10-year prospective community cohort study of 3021 adolescents and young adults, the association between persistence of affective symptoms over 3 years and the 10-year clinical outcomes of incident DSM-IV (hypo)manic episodes and incident use of mental healthcare was assessed. Results Transition to clinical outcome was associated with persistence of symptoms in a dose-dependent manner. Around 30-40% of clinical outcomes could be traced to prior persistence of affective symptoms. Conclusions In a substantial proportion of individuals, onset of clinical bipolar disorder may be seen as the poor outcome of a developmentally common and usually transitory non-clinical bipolar phenotype.
AB - Background Although (hypo)manic symptoms are common in adolescence, transition to adult bipolar disorder is infrequent. Aims To examine whether the risk of transition to bipolar disorder is conditional on the extent of persistence of subthreshold affective phenotypes. Method In a 10-year prospective community cohort study of 3021 adolescents and young adults, the association between persistence of affective symptoms over 3 years and the 10-year clinical outcomes of incident DSM-IV (hypo)manic episodes and incident use of mental healthcare was assessed. Results Transition to clinical outcome was associated with persistence of symptoms in a dose-dependent manner. Around 30-40% of clinical outcomes could be traced to prior persistence of affective symptoms. Conclusions In a substantial proportion of individuals, onset of clinical bipolar disorder may be seen as the poor outcome of a developmentally common and usually transitory non-clinical bipolar phenotype.
U2 - 10.1192/bjp.bp.109.065763
DO - 10.1192/bjp.bp.109.065763
M3 - Article
C2 - 20118453
SN - 0007-1250
VL - 196
SP - 102
EP - 108
JO - British Journal of Psychiatry
JF - British Journal of Psychiatry
IS - 2
ER -