TY - JOUR
T1 - Prediction of Alzheimer disease in subjects with amnestic and nonamnestic MCI
AU - Vos, Stephanie J. B.
AU - van Rossum, Ineke A.
AU - Verhey, Frans
AU - Knol, Dirk L.
AU - Soininen, Hilkka
AU - Wahlund, Lars-Olof
AU - Hampel, Harald
AU - Tsolaki, Magda
AU - Minthon, Lennart
AU - Frisoni, Giovanni B.
AU - Froelich, Lutz
AU - Nobili, Flavio
AU - van der Flier, Wiesje
AU - Blennow, Kaj
AU - Wolz, Robin
AU - Scheltens, Philip
AU - Visser, Pieter Jelle
PY - 2013/3
Y1 - 2013/3
N2 - Objective: To compare the predictive accuracy of beta-amyloid (A beta)1-42 and total tau in CSF, hippocampal volume (HCV), and APOE genotype for Alzheimer disease (AD)-type dementia in subjects with amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI). Methods: We selected 399 subjects with aMCI and 226 subjects with naMCI from a multicenter memory clinic-based cohort. We measured CSF A beta 1-42 and tau by ELISA (n = 231), HCV on MRI (n = 388), and APOE epsilon 4 (n = 523). Follow-up was performed annually up to 5 years. Outcome measures were progression to AD-type dementia and cognitive decline. Results: At least 1 follow-up was available for 538 subjects (86%). One hundred thirty-two subjects with aMCI (38%) and 39 subjects with naMCI (20%) progressed to AD-type dementia after an average follow-up of 2.5 years. CSF A beta 1-42, tau, A beta 1-42/tau ratio, HCV, and APOE epsilon 4 predicted AD-type dementia in each MCI subgroup with the same overall diagnostic accuracy. However, CSF A beta 1-42 concentration was higher and hippocampal atrophy less severe in subjects with naMCI compared with aMCI. This reduced the sensitivity but increased the specificity of these markers for AD-type dementia in subjects with naMCI. Conclusions: AD biomarkers are useful to predict AD-type dementia in subjects with aMCI and naMCI. However, biomarkers might not be as sensitive for early diagnosis of AD in naMCI compared with aMCI. This may have implications for clinical implementation of the National Institute on Aging and Alzheimer's Association criteria. Neurology (R) 2013; 80:1124-1132
AB - Objective: To compare the predictive accuracy of beta-amyloid (A beta)1-42 and total tau in CSF, hippocampal volume (HCV), and APOE genotype for Alzheimer disease (AD)-type dementia in subjects with amnestic mild cognitive impairment (aMCI) and nonamnestic mild cognitive impairment (naMCI). Methods: We selected 399 subjects with aMCI and 226 subjects with naMCI from a multicenter memory clinic-based cohort. We measured CSF A beta 1-42 and tau by ELISA (n = 231), HCV on MRI (n = 388), and APOE epsilon 4 (n = 523). Follow-up was performed annually up to 5 years. Outcome measures were progression to AD-type dementia and cognitive decline. Results: At least 1 follow-up was available for 538 subjects (86%). One hundred thirty-two subjects with aMCI (38%) and 39 subjects with naMCI (20%) progressed to AD-type dementia after an average follow-up of 2.5 years. CSF A beta 1-42, tau, A beta 1-42/tau ratio, HCV, and APOE epsilon 4 predicted AD-type dementia in each MCI subgroup with the same overall diagnostic accuracy. However, CSF A beta 1-42 concentration was higher and hippocampal atrophy less severe in subjects with naMCI compared with aMCI. This reduced the sensitivity but increased the specificity of these markers for AD-type dementia in subjects with naMCI. Conclusions: AD biomarkers are useful to predict AD-type dementia in subjects with aMCI and naMCI. However, biomarkers might not be as sensitive for early diagnosis of AD in naMCI compared with aMCI. This may have implications for clinical implementation of the National Institute on Aging and Alzheimer's Association criteria. Neurology (R) 2013; 80:1124-1132
U2 - 10.1212/WNL.0b013e318288690c
DO - 10.1212/WNL.0b013e318288690c
M3 - Article
C2 - 23446677
SN - 0028-3878
VL - 80
SP - 1124
EP - 1132
JO - Neurology
JF - Neurology
IS - 12
ER -