Predicting local tumour progression after ablation for colorectal liver metastases: CT-based radiomics of the ablation zone

F. C. R. Staal, M. Taghavi, D. J. van der Reijd, F. M. Gomez, F. Imani, E. G. Klompenhouwer, D. Meek, S. Roberti, M. de Boer, D. M. J. Lambregts, R. G. H. Beets-Tan, M. Maas*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

4 Citations (Web of Science)

Abstract

Purpose: To assess whether CT-based radiomics of the ablation zone (AZ) can predict local tumour progression (LTP) after thermal ablation for colorectal liver metastases (CRLM). Materials and methods: Eighty-two patients with 127 CRLM were included. Radiomics features (with different filters) were extracted from the AZ and a 10 mm periablational rim (PAR)on portal-venous-phase CT up to 8 weeks after ablation. Multivariable stepwise Cox regression analyses were used to predict LTP based on clinical and radiomics features. Performance (concordance [c]-statistics) of the different models was compared and performance in an 'independent' dataset was approximated with bootstrapped leave-one-out-cross-validation (LOOCV). Results: Thirty-three lesions (26 %) developed LTP. Median follow-up was 21 months (range 6-115). The combined model, a combination of clinical and radiomics features, included chemotherapy (HR 0.50, p = 0.024), cT-stage (HR 10.13, p = 0.016), lesion size (HR 1.11, p =

Original languageEnglish
Article number109773
Number of pages7
JournalEuropean Journal of Radiology
Volume141
DOIs
Publication statusPublished - Aug 2021

Keywords

  • Colorectal neoplasms
  • Radiofrequency ablation
  • Neoplasm metastasis
  • Liver
  • Ablation techniques
  • Neoplasm recurrence
  • Local
  • Tomography
  • X-ray computed
  • RADIOFREQUENCY ABLATION
  • CANCER PATIENTS
  • STANDARDIZATION
  • TERMINOLOGY
  • PERFORMANCE
  • RECURRENCE
  • SURVIVAL
  • CRITERIA
  • TEXTURE

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