TY - JOUR
T1 - Predicting hospitalization and mortality in patients with heart failure
T2 - The BARDICHE-index
AU - Uszko-Lencer, Nicole H. M. K.
AU - Frankenstein, Lutz
AU - Spruit, Martijn A.
AU - Maeder, Micha T.
AU - Gutmann, Marc
AU - Muzzarelli, Stefano
AU - Osswald, Stefan
AU - Pfisterer, Matthias E.
AU - Zugck, Christian
AU - Brunner-La Rocca, Hans-Peter
AU - Investigators, TIME-CHF
PY - 2017/1/15
Y1 - 2017/1/15
N2 - Background: Prediction of events in chronic heart failure (CHF) patients is still difficult and available scores are often complex to calculate. Therefore, we developed and validated a simple-to-use, multidimensional prognostic index for such patients.Methods: A theoretical model was developed based on known prognostic factors of CHF that are easily obtainable: Bodymass index (B), Age (A), Resting systolic blood pressure (R), Dyspnea (D), N-termInal pro brain natriuretic peptide (NT-proBNP) (I), Cockroft-Gault equation to estimate glomerular filtration rate (C), resting Heart rate (H), and Exercise performance using the 6-min walk test (E) (the BARDICHE-index). Scores were given for all components and added, the sumranging from1 (lowest value) to 25 points (maximal value), with estimated risk being highest in patients with highest scores. Scores were categorized into three groups: a low (Results: There were significant differences between BARDICHE-risk groups for mortality (hazard ratio = 3.63 per BARDICHE-group, 95%-CI 3.10-4.25), mortality or all-cause hospitalization (HR = 2.00 per BARDICHE-group, 95%-CI 1.83-2.19), and mortality or CHF-related hospitalization (HR = 3.43 per BARDICHE-group, 95%-CI 3.01-3.92; all P <10-50). Outcome was predicted independently of left ventricular ejection fraction (LVEF) and gender.Conclusions: The BARDICHE-index is a simple multidimensional prognostic tool for patients with CHF, independently of LVEF. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
AB - Background: Prediction of events in chronic heart failure (CHF) patients is still difficult and available scores are often complex to calculate. Therefore, we developed and validated a simple-to-use, multidimensional prognostic index for such patients.Methods: A theoretical model was developed based on known prognostic factors of CHF that are easily obtainable: Bodymass index (B), Age (A), Resting systolic blood pressure (R), Dyspnea (D), N-termInal pro brain natriuretic peptide (NT-proBNP) (I), Cockroft-Gault equation to estimate glomerular filtration rate (C), resting Heart rate (H), and Exercise performance using the 6-min walk test (E) (the BARDICHE-index). Scores were given for all components and added, the sumranging from1 (lowest value) to 25 points (maximal value), with estimated risk being highest in patients with highest scores. Scores were categorized into three groups: a low (Results: There were significant differences between BARDICHE-risk groups for mortality (hazard ratio = 3.63 per BARDICHE-group, 95%-CI 3.10-4.25), mortality or all-cause hospitalization (HR = 2.00 per BARDICHE-group, 95%-CI 1.83-2.19), and mortality or CHF-related hospitalization (HR = 3.43 per BARDICHE-group, 95%-CI 3.01-3.92; all P <10-50). Outcome was predicted independently of left ventricular ejection fraction (LVEF) and gender.Conclusions: The BARDICHE-index is a simple multidimensional prognostic tool for patients with CHF, independently of LVEF. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
KW - Chronic heart failure
KW - Prognostic model
KW - Survival
KW - RISK SCORE
KW - NT-PROBNP
KW - AMBULATORY PATIENTS
KW - MORBIDITY
KW - SURVIVAL
KW - MODEL
KW - VALIDATION
KW - PROGRAM
KW - MARKER
KW - RATES
U2 - 10.1016/j.ijcard.2016.11.122
DO - 10.1016/j.ijcard.2016.11.122
M3 - Article
SN - 0167-5273
VL - 227
SP - 901
EP - 907
JO - International Journal of Cardiology
JF - International Journal of Cardiology
ER -