Abstract
Cardiovascular disease is leading cause of death in the western societies, with dismal outlook even upon optimal treatment which underlines the necessity of better therapies. Urocortin-2 and urocortin-3 intravenous infusion improved heart function in humans. However, constant administration of these proteins is required for chronic treatment due to their short half-life (few minutes), a problem that could be solved by gene transfer of those peptides. This work demonstrates that one intravenous injection of adeno-associated virus encoding urocortin-2 or urocortin-3 increases cardiac function in mice. Furthermore, urocortin-2 gene transfer increased insulin sensitivity in mice. These findings support urocortin-2 and urocortin-3 gene transfer as potential treatment for heart failure and diabetes.
Original language | English |
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Awarding Institution |
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Award date | 5 Jun 2019 |
Place of Publication | Maastricht |
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Print ISBNs | 9789463236683 |
DOIs | |
Publication status | Published - 2019 |
Keywords
- Gene therapy
- Heart failure
- Insulin sensitivity
- contractile function
- diastolic function
- adeno-associated virus