Abstract
In circadian rhythm sleep-wake disorders precision medicine is less developed than in other medical disciplines mainly because homeostatic sleep and circadian timing have a very complex phenotype with multiple genetic regulation mechanisms. However, biomarkers, phenotyping and psychosocial characteristics are increasingly used. Devices for polysomnography, actigraphy and sleep-tracking applications in mobile phones and other consumer devices with eHealth technologies are increasingly used. Also sleep-related questionnaires and the assessment of co-morbidities influencing sleep in circadian rhythm sleep-wake disorders are major contributors to precision sleep medicine. To further strengthen the (pharmaco-)genetic and biomarker pillar, technology needs to be evolved further. Routinely measuring treatment results using patient-reported outcome measures and clinical neurophysiological instruments will boost precision sleep medicine.
Original language | English |
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Pages (from-to) | 171-182 |
Number of pages | 12 |
Journal | Personalized Medicine |
Volume | 14 |
Issue number | 2 |
DOIs | |
Publication status | Published - Mar 2017 |
Keywords
- biomarker
- DLMO
- genetics
- melatonin
- personalized medicine
- precision medicine
- sleep
- LIGHT MELATONIN ONSET
- COGNITIVE-BEHAVIORAL THERAPY
- RANDOMIZED CONTROLLED-TRIAL
- CAFFEINE URINARY METABOLITES
- NIGHT-SHIFT WORK
- BRIGHT LIGHT
- PERSONALIZED MEDICINE
- CYTOCHROME-P450 1A2
- PHASE DISORDER
- PINEAL-GLAND