Pre-hospital evaluation of chest pain patients using the modified HEART-score: rationale and design

Jaouad Azzahhafi; Dean Rpp Chan Pin Yin; Mirjam Epping; Hajar Bofarid; Sem Aof Rikken; Thijs Verhagen; Rene Boomars; Anja Radstok; Jaco Houtgraaf; Angela Bikker; Jurriën M Ten Berg

doi:10.1080/14796678.2024.2356995

Pre-hospital evaluation of chest pain patients using the modified HEART-score: rationale and design

Jaouad Azzahhafi^*, Dean Rpp Chan Pin Yin, Mirjam Epping, Hajar Bofarid, Sem Aof Rikken, Thijs Verhagen, Rene Boomars, Anja Radstok, Jaco Houtgraaf, Angela Bikker, Jurriën M Ten Berg

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: This study assesses how ambulance paramedics using the modified HEART-score with a point-of-care cardiac troponin (cTn) compare to the emergency physicians using the modified HEART-score with a high-sensitive cTn (hs-cTn) in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS), focusing on interobserver agreement and diagnostic performance. Methods: In this prospective multicenter cohort, we compare four cTn testing strategies (serial point of care and hs-cTn cTn measurement) with and without the HEART-score. Outcomes include the HEART-score's interobserver agreement, NSTE-ACS at discharge, major adverse cardiovascular events (MACE) after 30 days, and diagnostic accuracy of the different strategies. Conclusion: The POPular HEART study aims to improve NSTE-ACS diagnostic pathways, promoting pre-hospital detection and ruling out of NSTE-ACS to minimize unnecessary hospitalizations and associated costs. Clinical Trial Registration:NCT04851418 (ClinicalTrials.gov).

Original language	English
Pages (from-to)	241-250
Number of pages	10
Journal	Future Cardiology
Volume	20
Issue number	5-6
Early online date	28 Jun 2024
DOIs	https://doi.org/10.1080/14796678.2024.2356995
Publication status	Published - 2024

Keywords

HEART-score
NSTE-ACS
cardiac troponin
high-sensitive cardiac troponin
point-of-care testing
pre-hospital

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10.1080/14796678.2024.2356995

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title = "Pre-hospital evaluation of chest pain patients using the modified HEART-score: rationale and design",

abstract = "Background: This study assesses how ambulance paramedics using the modified HEART-score with a point-of-care cardiac troponin (cTn) compare to the emergency physicians using the modified HEART-score with a high-sensitive cTn (hs-cTn) in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS), focusing on interobserver agreement and diagnostic performance. Methods: In this prospective multicenter cohort, we compare four cTn testing strategies (serial point of care and hs-cTn cTn measurement) with and without the HEART-score. Outcomes include the HEART-score's interobserver agreement, NSTE-ACS at discharge, major adverse cardiovascular events (MACE) after 30 days, and diagnostic accuracy of the different strategies. Conclusion: The POPular HEART study aims to improve NSTE-ACS diagnostic pathways, promoting pre-hospital detection and ruling out of NSTE-ACS to minimize unnecessary hospitalizations and associated costs. Clinical Trial Registration:NCT04851418 (ClinicalTrials.gov).",

keywords = "HEART-score, NSTE-ACS, cardiac troponin, high-sensitive cardiac troponin, point-of-care testing, pre-hospital",

author = "Jaouad Azzahhafi and \{Chan Pin Yin\}, \{Dean Rpp\} and Mirjam Epping and Hajar Bofarid and Rikken, \{Sem Aof\} and Thijs Verhagen and Rene Boomars and Anja Radstok and Jaco Houtgraaf and Angela Bikker and \{Ten Berg\}, \{Jurri{\"e}n M\}",

year = "2024",

doi = "10.1080/14796678.2024.2356995",

language = "English",

volume = "20",

pages = "241--250",

journal = "Future Cardiology",

issn = "1479-6678",

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number = "5-6",

}

TY - JOUR

T1 - Pre-hospital evaluation of chest pain patients using the modified HEART-score

T2 - rationale and design

AU - Azzahhafi, Jaouad

AU - Chan Pin Yin, Dean Rpp

AU - Epping, Mirjam

AU - Bofarid, Hajar

AU - Rikken, Sem Aof

AU - Verhagen, Thijs

AU - Boomars, Rene

AU - Radstok, Anja

AU - Houtgraaf, Jaco

AU - Bikker, Angela

AU - Ten Berg, Jurriën M

PY - 2024

Y1 - 2024

N2 - Background: This study assesses how ambulance paramedics using the modified HEART-score with a point-of-care cardiac troponin (cTn) compare to the emergency physicians using the modified HEART-score with a high-sensitive cTn (hs-cTn) in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS), focusing on interobserver agreement and diagnostic performance. Methods: In this prospective multicenter cohort, we compare four cTn testing strategies (serial point of care and hs-cTn cTn measurement) with and without the HEART-score. Outcomes include the HEART-score's interobserver agreement, NSTE-ACS at discharge, major adverse cardiovascular events (MACE) after 30 days, and diagnostic accuracy of the different strategies. Conclusion: The POPular HEART study aims to improve NSTE-ACS diagnostic pathways, promoting pre-hospital detection and ruling out of NSTE-ACS to minimize unnecessary hospitalizations and associated costs. Clinical Trial Registration:NCT04851418 (ClinicalTrials.gov).

AB - Background: This study assesses how ambulance paramedics using the modified HEART-score with a point-of-care cardiac troponin (cTn) compare to the emergency physicians using the modified HEART-score with a high-sensitive cTn (hs-cTn) in patients with suspected non-ST-elevation acute coronary syndrome (NSTE-ACS), focusing on interobserver agreement and diagnostic performance. Methods: In this prospective multicenter cohort, we compare four cTn testing strategies (serial point of care and hs-cTn cTn measurement) with and without the HEART-score. Outcomes include the HEART-score's interobserver agreement, NSTE-ACS at discharge, major adverse cardiovascular events (MACE) after 30 days, and diagnostic accuracy of the different strategies. Conclusion: The POPular HEART study aims to improve NSTE-ACS diagnostic pathways, promoting pre-hospital detection and ruling out of NSTE-ACS to minimize unnecessary hospitalizations and associated costs. Clinical Trial Registration:NCT04851418 (ClinicalTrials.gov).

KW - HEART-score

KW - NSTE-ACS

KW - cardiac troponin

KW - high-sensitive cardiac troponin

KW - point-of-care testing

KW - pre-hospital

U2 - 10.1080/14796678.2024.2356995

DO - 10.1080/14796678.2024.2356995

M3 - Article

SN - 1479-6678

VL - 20

SP - 241

EP - 250

JO - Future Cardiology

JF - Future Cardiology

IS - 5-6

ER -

Pre-hospital evaluation of chest pain patients using the modified HEART-score: rationale and design

Abstract

Keywords

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