Practice points in gynecardiology: Abnormal uterine bleeding in premenopausal women taking oral anticoagulant or antiplatelet therapy

Angela H. E. M. Maas*, Mia von Euler, Marlies Y. Bongers, Herbert J. A. Rolden, Janneke P. C. Grutters, Lian Ulrich, Karin Schenck-Gustafsson

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)


A growing number of premenopausal women are currently using antithrombotic and/or (dual) antiplatelet therapy for various cardiovascular indications. These may induce or exacerbate abnormal uterine bleeding and more awareness and knowledge among prescribers is required. Heavy and irregular menstrual bleeding is common in women in their forties and may have a variety of underlying causes that require different treatment options. Thus using anticoagulants in premenopausal women demands specific expertise and close collaboration between cardiovascular physicians and gynecologists. In this article we summarize the scope of the problem and provide practical recommendations for the care for young women taking anticoagulants and/or (dual) antiplatelet therapy. We also recommend that more safety data on uterine bleeding with novel anticoagulants in premenopausal women should be obtained.
Original languageEnglish
Pages (from-to)355-359
Issue number4
Publication statusPublished - Dec 2015


  • Abnormal uterine bleeding
  • Anticoagulants
  • Antiplatelet therapy
  • Gynecardiology
  • Novel oral anticoagulants

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