Potential cell-specific functions of CXCR4 in atherosclerosis

Christian Weber*, Yvonne Doering, Heidi Noels

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

The chemokine CXCL12 and its receptor CXCR4 form an important axis contributing to cellular functions in homeostasis and disease. In addition, the atypical CXCL12 receptor CXCR7 may shape the availability and function of CXCL12. Further to their role through progenitor cell mobilization, CXCL12 and CXCR4 may affect native atherogenesis by modifying atherosclerosis-relevant cellular functions. This short review intends to provide a concise summary of current knowledge with regards to cell-specific functions of CXCL12 and its receptors CXCR4 and CXCR7 with potential implications for the initiation and progression of atherosclerosis.
Original languageEnglish
Pages (from-to)97-102
JournalHämostaseologie
Volume36
Issue number2
DOIs
Publication statusPublished - May 2016

Keywords

  • CXCL12
  • CXCR4
  • CXCR7

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