AIM: Although postprandial hyperglycemia is recognized as an important target in type 2 diabetes treatment, information on the prevalence of postprandial hyperglycemia throughout the day is limited. Therefore, we assessed the prevalence of hyperglycemia throughout the day in type 2 diabetes patients and healthy controls under standardized dietary, but otherwise free-living conditions. METHODS: 60 male type 2 diabetes patients (HbA(1c) 7.5+/-0.1% [58+/-1mmol/mol]) and 24 age- and BMI-matched normal glucose tolerant controls were recruited to participate in a comparative study of daily glycemic control. During a 3-day experimental period, blood glucose concentrations throughout the day were assessed by continuous glucose monitoring. RESULTS: Type 2 diabetes patients experienced hyperglycemia (glucose concentrations >10mmol/L) 38+/-4% of the day. Even diabetes patients with an HbA(1c) level below 7.0% (53mmol/mol) experienced hyperglycemia for as much as 24+/-5% throughout the day. Hyperglycemia was negligible in the control group (3+/-1%). CONCLUSION: Hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients, even in those patients with a HbA(1c) level well below 7.0% (53mmol/mol). Standard medical care with prescription of oral blood glucose lowering medication does not provide ample protection against postprandial hyperglycemia.
van Dijk, J. W. M., Manders, R. J. F., Hartgens, F., Stehouwer, C. D. A., Praet, S. F., & van Loon, L. J. C. (2011). Postprandial hyperglycemia is highly prevalent throughout the day in type 2 diabetes patients. Diabetes Research and Clinical Practice, 93(1), 31-37. https://doi.org/10.1016/j.diabres.2011.03.021