Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support

Sjoukje I. Lok; Alain van Mil; Niels Bovenschen; Petra van der Weide; Joyce van Kuik; Dick van Wichen; Ton Peeters; Erica Siera; Bjorn Winkens; Joost P. G. Sluijter; Pieter A. Doevendans; Paula A. da Costa Martins; Nicolaas de Jonge; Roel A. de Weger

doi:10.1161/CIRCHEARTFAILURE.112.000255

Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support

Sjoukje I. Lok^*
, Alain van Mil
, Niels Bovenschen
, Petra van der Weide
, Joyce van Kuik
, Dick van Wichen
, Ton Peeters
, Erica Siera
, Bjorn Winkens
, Joost P. G. Sluijter
, Pieter A. Doevendans
, Paula A. da Costa Martins
, Nicolaas de Jonge
, Roel A. de Weger

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in -1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Methods and Results Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P

Original language	English
Pages (from-to)	853-861
Number of pages	9
Journal	Circulation-Heart Failure
Volume	6
Issue number	4
DOIs	https://doi.org/10.1161/CIRCHEARTFAILURE.112.000255
Publication status	Published - Jul 2013

Keywords

ACT
heart failure
LVAD
remodeling
serpina-3

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10.1161/CIRCHEARTFAILURE.112.000255

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Lok, S. I., van Mil, A., Bovenschen, N., van der Weide, P., van Kuik, J., van Wichen, D., Peeters, T., Siera, E., Winkens, B., Sluijter, J. P. G., Doevendans, P. A., Martins, P. A. D. C., de Jonge, N., & de Weger, R. A. (2013). Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support. Circulation-Heart Failure, 6(4), 853-861. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000255

@article{5b6b060621684bd5a0ad4793d2a935c9,

title = "Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support",

abstract = "Background Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in -1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Methods and Results Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P",

keywords = "ACT, heart failure, LVAD, remodeling, serpina-3",

author = "Lok, \{Sjoukje I.\} and \{van Mil\}, Alain and Niels Bovenschen and \{van der Weide\}, Petra and \{van Kuik\}, Joyce and \{van Wichen\}, Dick and Ton Peeters and Erica Siera and Bjorn Winkens and Sluijter, \{Joost P. G.\} and Doevendans, \{Pieter A.\} and Martins, \{Paula A. da Costa\} and \{de Jonge\}, Nicolaas and \{de Weger\}, \{Roel A.\}",

year = "2013",

month = jul,

doi = "10.1161/CIRCHEARTFAILURE.112.000255",

language = "English",

volume = "6",

pages = "853--861",

journal = "Circulation-Heart Failure",

issn = "1941-3289",

publisher = "Lippincott Williams \& Wilkins",

number = "4",

}

Lok, SI, van Mil, A, Bovenschen, N, van der Weide, P, van Kuik, J, van Wichen, D, Peeters, T, Siera, E, Winkens, B, Sluijter, JPG, Doevendans, PA, Martins, PADC, de Jonge, N & de Weger, RA 2013, 'Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support', Circulation-Heart Failure, vol. 6, no. 4, pp. 853-861. https://doi.org/10.1161/CIRCHEARTFAILURE.112.000255

TY - JOUR

T1 - Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support

AU - Lok, Sjoukje I.

AU - van Mil, Alain

AU - Bovenschen, Niels

AU - van der Weide, Petra

AU - van Kuik, Joyce

AU - van Wichen, Dick

AU - Peeters, Ton

AU - Siera, Erica

AU - Winkens, Bjorn

AU - Sluijter, Joost P. G.

AU - Doevendans, Pieter A.

AU - Martins, Paula A. da Costa

AU - de Jonge, Nicolaas

AU - de Weger, Roel A.

PY - 2013/7

Y1 - 2013/7

N2 - Background Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in -1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Methods and Results Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P

AB - Background Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in -1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Methods and Results Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P

KW - ACT

KW - heart failure

KW - LVAD

KW - remodeling

KW - serpina-3

U2 - 10.1161/CIRCHEARTFAILURE.112.000255

DO - 10.1161/CIRCHEARTFAILURE.112.000255

M3 - Article

C2 - 23640964

SN - 1941-3289

VL - 6

SP - 853

EP - 861

JO - Circulation-Heart Failure

JF - Circulation-Heart Failure

IS - 4

ER -

Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support

Abstract

Keywords

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