Abstract
Background Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in -1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Methods and Results Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P
Original language | English |
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Pages (from-to) | 853-861 |
Journal | Circulation-Heart Failure |
Volume | 6 |
Issue number | 4 |
DOIs | |
Publication status | Published - Jul 2013 |
Keywords
- ACT
- heart failure
- LVAD
- remodeling
- serpina-3