Post-transcriptional Regulation of a-1-Antichymotrypsin by MicroRNA-137 in Chronic Heart Failure and Mechanical Support

Sjoukje I. Lok*, Alain van Mil, Niels Bovenschen, Petra van der Weide, Joyce van Kuik, Dick van Wichen, Ton Peeters, Erica Siera, Bjorn Winkens, Joost P. G. Sluijter, Pieter A. Doevendans, Paula A. da Costa Martins, Nicolaas de Jonge, Roel A. de Weger

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Background Better understanding of the molecular mechanisms of remodeling has become a major objective of heart failure (HF) research to stop or reverse its progression. Left ventricular assist devices (LVADs) are being used in patients with HF, leading to partial reverse remodeling. In the present study, proteomics identified significant changes in -1-antichymotrypsin (ACT) levels during LVAD support. Moreover, the potential role of ACT in reverse remodeling was studied in detail. Methods and Results Expression of ACT mRNA (quantitative-polymerase chain reaction) decreased significantly in post-LVAD myocardial tissue compared with pre-LVAD tissue (n=15; P
Original languageEnglish
Pages (from-to)853-861
JournalCirculation-Heart Failure
Volume6
Issue number4
DOIs
Publication statusPublished - Jul 2013

Keywords

  • ACT
  • heart failure
  • LVAD
  • remodeling
  • serpina-3

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