Polyphosphate-Based Hydrogels as Drug-Loaded Wound Dressing: An In Vitro Study

R. Marroquin-Garcia*, J. Royakkers*, M. Gagliardi, R. Arreguin-Campos, T.J. Cleij, K. Eersels, N.M.S. van den Akker, D.G.M. Molin, B. van Grinsven, H. Dilien

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Hydrogels are interesting materials for application in biomedicine due to their outstanding properties (e.g., water retention, drug release, and biocompatibility). This work evaluates two series of phosphorus-based hydrogels as potential wounddressing candidates. The materials were synthesized via free-radical polymerization of bis[2-(methacryloyloxy)ethyl] phosphate (BMEP, >= 75 wt %) with (3-acryl amidopropyl)-trimethylammonium chloride solution (APTAC) or 2-acrylamido-2-methyl-1-propane sulfonic acid (AMPS). Due to optimized synthetic conditions, the materials displayed an unprecedented compressive elastic modulus (E') reaching up to 0.19 MPa, which represents a 1000-fold increase compared to previously reported materials. Furthermore, the hydrogels displayed good hydrolytic and enzymatic stability, cytocompatibility using bovine fibroblasts (BFs), and drug loading/release in woundlike pH conditions. In summary, this work demonstrates the potential of phosphorusbased hydrogels as drug-eluting wound-dressing materials.
Original languageEnglish
Pages (from-to)2871-2879
Number of pages9
JournalACS Applied Polymer Materials
Issue number4
Publication statusPublished - 8 Apr 2022


  • poly(phosphodiesters)
  • poly(phosphates)
  • hydrogels
  • wound dressing
  • drug delivery
  • cytocompatibility
  • mechanical properties
  • ACID

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