Polylactides in additive biomanufacturing

Patrina S P Poh, Mohit P Chhaya, Felix M Wunner, Elena M De-Juan-Pardo, Arndt F Schilling, Jan-Thorsten Schantz, Martijn van Griensven, Dietmar W Hutmacher*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

Abstract

New advanced manufacturing technologies under the alias of additive biomanufacturing allow the design and fabrication of a range of products from pre-operative models, cutting guides and medical devices to scaffolds. The process of printing in 3 dimensions of cells, extracellular matrix (ECM) and biomaterials (bioinks, powders, etc.) to generate in vitro and/or in vivo tissue analogue structures has been termed bioprinting. To further advance in additive biomanufacturing, there are many aspects that we can learn from the wider additive manufacturing (AM) industry, which have progressed tremendously since its introduction into the manufacturing sector. First, this review gives an overview of additive manufacturing and both industry and academia efforts in addressing specific challenges in the AM technologies to drive toward AM-enabled industrial revolution. After which, considerations of poly(lactides) as a biomaterial in additive biomanufacturing are discussed. Challenges in wider additive biomanufacturing field are discussed in terms of (a) biomaterials; (b) computer-aided design, engineering and manufacturing; (c) AM and additive biomanufacturing printers hardware; and (d) system integration. Finally, the outlook for additive biomanufacturing was discussed.

Original languageEnglish
Pages (from-to)228-246
Number of pages19
JournalAdvanced Drug Delivery Reviews
Volume107
DOIs
Publication statusPublished - 15 Dec 2016
Externally publishedYes

Keywords

  • Biocompatible Materials/chemical synthesis
  • Bioprinting/instrumentation
  • Computer-Aided Design
  • Manufactured Materials
  • Polyesters/chemical synthesis
  • POLYCAPROLACTONE SCAFFOLDS
  • Bioprinting
  • Computer-aided engineering
  • ARCHITECTURE DESIGN
  • LASER
  • TISSUE
  • POLY-L-LACTIDE
  • Additive manufacturing
  • Computer-aided design
  • BREAST RECONSTRUCTION
  • Computer-aided manufacturing
  • THERMAL-DEGRADATION
  • STERILIZATION
  • RESIDUAL-STRESSES
  • COMPUTER-AIDED-DESIGN
  • Tissue engineering and regenerative medicine
  • Poly(lactic acids)
  • 3D printing

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