Polyglutamine aggregation in Huntington's disease and spinocerebellar ataxia type 3: similar mechanisms in aggregate formation

Keyphrases

• Brain Regions 100%
• Polyglutamine Aggregation 100%
• Aggregate Formation 100%
• Huntington's Disease 100%
• Spinocerebellar Ataxia Type 3 (SCA3) 100%
• Protein Quality Control 66%
• Disease-related Proteins 66%
• Protein Aggregation 66%
• PolyQ Aggregation 66%
• Dysregulation 33%
• Neurodegeneration 33%
• Proteasomal Degradation 33%
• Peri 33%
• Neuronal Dysfunction 33%
• Brain Diseases 33%
• Glutamine 33%
• Degradation Pathway 33%
• Lysosomal Degradation 33%
• Inclusion Formation 33%
• Protein Aggregates 33%
• Nuclear Inclusions 33%
• Chaperone 33%
• Protein Quality Control System 33%
• Polyglutamine Disease 33%
• PolyQ Proteins 33%
• Cellular Proteins 33%
• Distinct Patterns 33%
• Cellular Stress Response 33%
• DNAJB1 33%
• Intranuclear 33%
• HSPA1A 33%
• Cytoplasmic Inclusions 33%
• Neuronal Death 33%
• PolyQ Diseases 33%
• Observed Effects 33%
• Perikaryon 33%
• Intranuclear Inclusion Bodies 33%
• Proteasome Dysfunction 33%

INIS

• proteins 100%
• aggregation 100%
• nervous system diseases 100%
• diseases 55%
• inclusions 44%
• brain 33%
• quality control 33%
• neurons 22%
• patients 11%
• regulations 11%
• pathology 11%
• death 11%
• populations 11%
• induction 11%
• distribution 11%
• expansion 11%
• control systems 11%
• glutamine 11%

Neuroscience

• Huntington's Disease 100%
• Polyglutamine 100%
• Spinocerebellar Ataxia 100%
• Brain Areas 28%
• Protein Aggregation 28%
• Neurodegeneration 14%
• Glutamine 14%
• Cellular Stress Response 14%
• Perikaryon 14%
• Cell Protein 14%
• Protein Aggregate 14%