Abstract
Objective To test whether polygenic risk score for schizophrenia (PRS-S) interacts with childhood adversity and daily-life stressors to influence momentary mental state domains (negative affect, positive affect, and subtle psychosis expression) and stress-sensitivity measures.
Methods The data were retrieved from a general population twin cohort including 593 adolescents and young adults. Childhood adversity was assessed using the Childhood Trauma Questionnaire. Daily-life stressors and momentary mental state domains were measured using ecological momentary assessment. PRS-S was trained on the latest Psychiatric Genetics Consortium schizophrenia meta-analysis. The analyses were conducted using multilevel mixed-effects tobit regression models.
Results Both childhood adversity and daily-life stressors were associated with increased negative affect, decreased positive affect, and increased subtle psychosis expression, while PRS-S was only associated with increased positive affect. No gene-environment correlation was detected. There is novel evidence for interaction effects between PRS-S and childhood adversity to influence momentary mental states [negative affect (b = 0.07, P = 0.013), positive affect (b = -0.05, P = 0.043), and subtle psychosis expression (b = 0.11, P = 0.007)] and stress-sensitivity measures.
Conclusion Exposure to childhood adversities, particularly in individuals with high PRS-S, is pleiotropically associated with emotion dysregulation and psychosis proneness.
Original language | English |
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Pages (from-to) | 465-475 |
Number of pages | 11 |
Journal | Acta Psychiatrica Scandinavica |
Volume | 141 |
Issue number | 5 |
DOIs | |
Publication status | Published - May 2020 |
Keywords
- gene-environment interaction
- psychosis
- childhood trauma
- daily-life stressors
- experience sampling method
- emotion regulation
- GENE-ENVIRONMENT INTERACTIONS
- EXPERIENCE SAMPLING RESEARCH
- STRESS-REACTIVITY
- RISK SCORES
- TRAUMA
- SENSITIVITY
- DISORDER
- ASSOCIATION
- PSYCHOPATHOLOGY
- POLYMORPHISM