Pleiotropic-acting nutrients require integrative investigational approaches: the example of flavonoids.

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Abstract

Assessment of the health effects of dietary interventions in humans poses a particular challenge to nutritional and clinical scientists. In contrast to drugs possessing a well-defined molecular mechanism of action, food-derived components act in subtle and pleiotropic ways by nature. Moreover, dietary compounds are mainly not intended to cure a disease but to prevent or beneficially affect situations when the physiology gets slightly out of homeostasis. By the example of a recent clinical pilot study, this paper illustrates an endeavor to find new strategies for the detection of health effects of flavonoids in the human vasculature. Integration of a meticulously selected cluster of relevant biomarkers eventually enabled the beneficial vascular health effects of flavonoids to be revealed. A critical appraisal of this approach for the future is provided.

Original languageEnglish
Pages (from-to)8941-8946
Number of pages6
JournalJournal of Agricultural and Food Chemistry
Volume60
Issue number36
DOIs
Publication statusPublished - 12 Sep 2012

Keywords

  • flavonoids
  • nutrients
  • antioxidants
  • vascular health
  • inflammation
  • integration
  • biomarkers
  • risk factors
  • end points
  • health index
  • clinical study
  • NADPH-OXIDASE
  • ANTIOXIDANT
  • ENDOTHELIUM
  • DISEASE
  • BLOOD
  • INHIBITION
  • MODULATION
  • MECHANISMS
  • SMOKING
  • HEALTH

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