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Platelets, red blood cells, fibrinogen and endothelial cells: Essential components in blood clotting

  • Siyu Sun

Research output: ThesisDoctoral ThesisInternal

Abstract

Blood clotting is essential for preventing excessive bleeding after an injury, but when the process is not properly controlled, it can lead to serious health issues such as thrombosis (dangerous blood clots) or excessive bleeding. This research focuses on understanding how blood clots form and the different factors that influence their stability. By studying the interactions between specific blood components, it aims to uncover new insights into how clotting is regulated and how it might be affected by medications or diseases. The goal is to improve knowledge of the body’s natural clotting mechanisms and identify potential ways to prevent or treat clotting disorders. The findings from this work could help develop better diagnostic tools and treatments for conditions where blood clots are either too weak or too strong, ultimately improving patient care and outcomes.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Heemskerk, Johan W. M., Supervisor
  • de Laat, Bas, Co-Supervisor, External person
  • Roest, Mark, Co-Supervisor, External person
Award date24 Mar 2025
Place of PublicationMaastricht
Publication statusPublished - 24 Mar 2025

Keywords

  • Thrombin
  • platelets
  • red blood cells
  • fibrin

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