Abstract
Platelets have an important role in tumor angiogenesis, growth, and metastasis. The reciprocal interaction between cancer and platelets results in changes of several platelet characteristics. It is becoming clear that analysis of these platelet features could offer a new strategy in the search for biomarkers of cancer. Here, we review the human studies in which platelet characteristics (e.g., count, volume, protein, and mRNA content) are investigated in early-stage cancer. The main focus of this paper is to evaluate which platelet features are suitable for the development of a blood test that could detect cancer in its early stages.
Original language | English |
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Pages (from-to) | 563-573 |
Number of pages | 11 |
Journal | Cancer and Metastasis Reviews |
Volume | 40 |
Issue number | 2 |
Early online date | 26 Feb 2021 |
DOIs | |
Publication status | Published - Jun 2021 |
Keywords
- Biomarker
- Cancer
- Early-stage
- Platelets
- biomarker
- cancer
- early-stage
- platelets
- CELLS
- METASTASIS
- ANGIOGENESIS
- ASPIRIN
- BIOMARKERS
- PARANEOPLASTIC THROMBOCYTOSIS
- COLORECTAL-CANCER
- PROSTATE-CANCER
- VOLUME MPV
- TUMOR STROMA