Platelet proteomics: from discovery to diagnosis

Christina Loosse, Frauke Swieringa, Johan W. M. Heemskerk, Albert Sickmann, Christin Lorenz*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

Abstract

Introduction: Platelets are the smallest cells within the circulating blood with key roles in physiological hemostasis and pathological thrombosis regulated by the onset of activating/inhibiting processes via receptor responses and signaling cascades.Areas covered: Proteomics as well as genomic approaches have been fundamental in identifying and quantifying potential targets for future diagnostic strategies in the prevention of bleeding and thrombosis, and uncovering the complexity of platelet functions in health and disease. In this article, we provide a critical overview on current functional tests used in diagnostics and the future perspectives for platelet proteomics in clinical applications.Expert commentary: Proteomics represents a valuable tool for the identification of patients with diverse platelet associated defects. In-depth validation of identified biomarkers, e.g. receptors, signaling proteins, post-translational modifications, in large cohorts is decisive for translation into routine clinical diagnostics.
Original languageEnglish
Pages (from-to)467-476
Number of pages10
JournalExpert Review of Proteomics
Volume15
Issue number6
DOIs
Publication statusPublished - 1 Jan 2018

Keywords

  • Cardiovascular disease
  • hemostasis
  • mass spectrometry
  • platelets
  • proteomics
  • quantification
  • ELEVATION MYOCARDIAL-INFARCTION
  • THROMBUS FORMATION
  • ACTIVATED PLATELETS
  • MASS-SPECTROMETRY
  • PROTEIN QUANTITATION
  • O-GLYCOSYLATION
  • GLOBAL PROTEOME
  • SCOTT SYNDROME
  • IN-VIVO
  • REVEALS

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