Platelet populations and priming in hematological diseases

Constance C. F. M. J. Baaten, Hugo ten Cate, Paola E. J. van der Meijden*, Johan W. M. Heemskerk*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

41 Citations (Web of Science)
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Abstract

In healthy subjects and patients with hematological diseases, platelet populations can be distinguished with different response spectra in hemostatic and vascular processes. These populations partly overlap, and are less distinct than those of leukocytes. The platelet heterogeneity is linked to structural properties, and is enforced by inequalities in the environment. Contributing factors are variability between megakaryocytes, platelet ageing, and positive or negative priming of platelets during their time in circulation. Within a hemostatic plug or thrombus, platelet heterogeneity is enhanced by unequal exposure to agonists, with populations of contracted platelets in the thrombus core, discoid platelets at the thrombus surface, patches of ballooned and procoagulant platelets forming thrombin, and coated platelets binding fibrin. Several pathophysiological hematological conditions can positively or negatively prime the responsiveness of platelet populations. As a consequence, in vivo and in vitro markers of platelet activation can differ in thrombotic and hematological disorders.

Original languageEnglish
Pages (from-to)389-399
Number of pages11
JournalBlood Reviews
Volume31
Issue number6
DOIs
Publication statusPublished - Nov 2017

Keywords

  • Activation markers
  • Platelet heterogeneity
  • Positive priming
  • Thrombus
  • DEPENDENT FIBRIN FORMATION
  • ACUTE ISCHEMIC-STROKE
  • VON-WILLEBRAND-FACTOR
  • THROMBUS FORMATION
  • RETICULATED PLATELETS
  • PROCOAGULANT PLATELETS
  • GLYCOPROTEIN VI
  • INTEGRIN ALPHA(IIB)BETA(3)
  • DIABETES-MELLITUS
  • COATED-PLATELETS

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