Abstract
In healthy subjects and patients with hematological diseases, platelet populations can be distinguished with different response spectra in hemostatic and vascular processes. These populations partly overlap, and are less distinct than those of leukocytes. The platelet heterogeneity is linked to structural properties, and is enforced by inequalities in the environment. Contributing factors are variability between megakaryocytes, platelet ageing, and positive or negative priming of platelets during their time in circulation. Within a hemostatic plug or thrombus, platelet heterogeneity is enhanced by unequal exposure to agonists, with populations of contracted platelets in the thrombus core, discoid platelets at the thrombus surface, patches of ballooned and procoagulant platelets forming thrombin, and coated platelets binding fibrin. Several pathophysiological hematological conditions can positively or negatively prime the responsiveness of platelet populations. As a consequence, in vivo and in vitro markers of platelet activation can differ in thrombotic and hematological disorders.
Original language | English |
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Pages (from-to) | 389-399 |
Number of pages | 11 |
Journal | Blood Reviews |
Volume | 31 |
Issue number | 6 |
DOIs | |
Publication status | Published - Nov 2017 |
Keywords
- Activation markers
- Platelet heterogeneity
- Positive priming
- Thrombus
- DEPENDENT FIBRIN FORMATION
- ACUTE ISCHEMIC-STROKE
- VON-WILLEBRAND-FACTOR
- THROMBUS FORMATION
- RETICULATED PLATELETS
- PROCOAGULANT PLATELETS
- GLYCOPROTEIN VI
- INTEGRIN ALPHA(IIB)BETA(3)
- DIABETES-MELLITUS
- COATED-PLATELETS