Plasma Volume Changes in Pregnancy

Marc E.A. Spaanderman, Anneleen S. Staelens

Research output: Chapter in Book/Report/Conference proceedingChapterAcademic

Abstract

Under healthy conditions, only one-third of the plasma volume is located in the arterial compartment, whereas the remainder is located in the venous compartment to balance increased arterial demands. In normotensive formerly preeclamptic women, about half have low plasma volume, a condition paralleled by reduced venous compliance, blunted responsiveness to orthostatic stress and consistently higher sympathetic tone. Low plasma volume therefore seems to represent reduced venous reserve capacity. Functionally, prepregnancy low plasma volume predisposes to early-pregnancy circulatory maladaptation; clinically, it relates to increased risk on recurrent hypertensive disease, growth restriction and preterm birth. Modulation of the plasma volume compartment may therefore reduce the risk of recurrent gestational hypertensive sequellae in women with prepregnancy reduced plasma volume.
Original languageEnglish
Title of host publicationMaternal Hemodynamics
EditorsChristoph Lees, Wilfried Gyselaers
PublisherCambridge University Press
Pages58-68
Number of pages11
ISBN (Electronic)9781316661925
ISBN (Print)9781107157378
DOIs
Publication statusPublished - 1 Jan 2018

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