Abstract
Under healthy conditions, only one-third of the plasma volume is located in the arterial compartment, whereas the remainder is located in the venous compartment to balance increased arterial demands. In normotensive formerly preeclamptic women, about half have low plasma volume, a condition paralleled by reduced venous compliance, blunted responsiveness to orthostatic stress and consistently higher sympathetic tone. Low plasma volume therefore seems to represent reduced venous reserve capacity. Functionally, prepregnancy low plasma volume predisposes to early-pregnancy circulatory maladaptation; clinically, it relates to increased risk on recurrent hypertensive disease, growth restriction and preterm birth. Modulation of the plasma volume compartment may therefore reduce the risk of recurrent gestational hypertensive sequellae in women with prepregnancy reduced plasma volume.
Original language | English |
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Title of host publication | Maternal Hemodynamics |
Editors | Christoph Lees, Wilfried Gyselaers |
Publisher | Cambridge University Press |
Pages | 58-68 |
Number of pages | 11 |
ISBN (Electronic) | 9781316661925 |
ISBN (Print) | 9781107157378 |
DOIs | |
Publication status | Published - 1 Jan 2018 |