Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

K. J. Vinknes; J. M. Dekker; C. A. Drevon; H. Refsum; E. Nurk; G. Nijpels; C. D. A. Stehouwer; T. Teerlink; G. S. Tell; O. Nygard; S. E. Vollset; P. M. Ueland; A. K. Elshorbagy

doi:10.1016/j.plefa.2013.09.007

Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

K. J. Vinknes^*
, J. M. Dekker
, C. A. Drevon
, H. Refsum
, E. Nurk
, G. Nijpels
, C. D. A. Stehouwer
, T. Teerlink
, G. S. Tell
, O. Nygard
, S. E. Vollset
, P. M. Ueland
, A. K. Elshorbagy

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P

Original language	English
Pages (from-to)	297-303
Number of pages	7
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	89
Issue number	5
DOIs	https://doi.org/10.1016/j.plefa.2013.09.007
Publication status	Published - Oct 2013

Keywords

Cysteine
Sulfur amino acids
Stearoyl-CoA desaturase
Fatty acid profile

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Vinknes, K. J., Dekker, J. M., Drevon, C. A., Refsum, H., Nurk, E., Nijpels, G., Stehouwer, C. D. A., Teerlink, T., Tell, G. S., Nygard, O., Vollset, S. E., Ueland, P. M., & Elshorbagy, A. K. (2013). Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations. Prostaglandins Leukotrienes and Essential Fatty Acids, 89(5), 297-303. https://doi.org/10.1016/j.plefa.2013.09.007

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title = "Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations",

abstract = "In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P",

keywords = "Cysteine, Sulfur amino acids, Stearoyl-CoA desaturase, Fatty acid profile",

author = "Vinknes, \{K. J.\} and Dekker, \{J. M.\} and Drevon, \{C. A.\} and H. Refsum and E. Nurk and G. Nijpels and Stehouwer, \{C. D. A.\} and T. Teerlink and Tell, \{G. S.\} and O. Nygard and Vollset, \{S. E.\} and Ueland, \{P. M.\} and Elshorbagy, \{A. K.\}",

year = "2013",

month = oct,

doi = "10.1016/j.plefa.2013.09.007",

language = "English",

volume = "89",

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Vinknes, KJ, Dekker, JM, Drevon, CA, Refsum, H, Nurk, E, Nijpels, G, Stehouwer, CDA, Teerlink, T, Tell, GS, Nygard, O, Vollset, SE, Ueland, PM & Elshorbagy, AK 2013, 'Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 89, no. 5, pp. 297-303. https://doi.org/10.1016/j.plefa.2013.09.007

TY - JOUR

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AU - Vinknes, K. J.

AU - Dekker, J. M.

AU - Drevon, C. A.

AU - Refsum, H.

AU - Nurk, E.

AU - Nijpels, G.

AU - Stehouwer, C. D. A.

AU - Teerlink, T.

AU - Tell, G. S.

AU - Nygard, O.

AU - Vollset, S. E.

AU - Ueland, P. M.

AU - Elshorbagy, A. K.

PY - 2013/10

Y1 - 2013/10

N2 - In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P

AB - In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P

KW - Cysteine

KW - Sulfur amino acids

KW - Stearoyl-CoA desaturase

KW - Fatty acid profile

U2 - 10.1016/j.plefa.2013.09.007

DO - 10.1016/j.plefa.2013.09.007

M3 - Article

C2 - 24120123

SN - 0952-3278

VL - 89

SP - 297

EP - 303

JO - Prostaglandins Leukotrienes and Essential Fatty Acids

JF - Prostaglandins Leukotrienes and Essential Fatty Acids

IS - 5

ER -

Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

Abstract

Keywords

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