Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

K. J. Vinknes*, J. M. Dekker, C. A. Drevon, H. Refsum, E. Nurk, G. Nijpels, C. D. A. Stehouwer, T. Teerlink, G. S. Tell, O. Nygard, S. E. Vollset, P. M. Ueland, A. K. Elshorbagy

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P
Original languageEnglish
Pages (from-to)297-303
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume89
Issue number5
DOIs
Publication statusPublished - Oct 2013

Keywords

  • Cysteine
  • Sulfur amino acids
  • Stearoyl-CoA desaturase
  • Fatty acid profile

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