Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

K. J. Vinknes; J. M. Dekker; C. A. Drevon; H. Refsum; E. Nurk; G. Nijpels; C. D. A. Stehouwer; T. Teerlink; G. S. Tell; O. Nygard; S. E. Vollset; P. M. Ueland; A. K. Elshorbagy

doi:10.1016/j.plefa.2013.09.007

Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations

K. J. Vinknes^*, J. M. Dekker, C. A. Drevon, H. Refsum, E. Nurk, G. Nijpels, C. D. A. Stehouwer, T. Teerlink, G. S. Tell, O. Nygard, S. E. Vollset, P. M. Ueland, A. K. Elshorbagy

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P

Original language	English
Pages (from-to)	297-303
Journal	Prostaglandins Leukotrienes and Essential Fatty Acids
Volume	89
Issue number	5
DOIs	https://doi.org/10.1016/j.plefa.2013.09.007
Publication status	Published - Oct 2013

Keywords

Cysteine
Sulfur amino acids
Stearoyl-CoA desaturase
Fatty acid profile

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10.1016/j.plefa.2013.09.007

Cite this

Vinknes, K. J., Dekker, J. M., Drevon, C. A., Refsum, H., Nurk, E., Nijpels, G., Stehouwer, C. D. A., Teerlink, T., Tell, G. S., Nygard, O., Vollset, S. E., Ueland, P. M., & Elshorbagy, A. K. (2013). Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations. Prostaglandins Leukotrienes and Essential Fatty Acids, 89(5), 297-303. https://doi.org/10.1016/j.plefa.2013.09.007

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abstract = "In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P",

keywords = "Cysteine, Sulfur amino acids, Stearoyl-CoA desaturase, Fatty acid profile",

author = "Vinknes, {K. J.} and Dekker, {J. M.} and Drevon, {C. A.} and H. Refsum and E. Nurk and G. Nijpels and Stehouwer, {C. D. A.} and T. Teerlink and Tell, {G. S.} and O. Nygard and Vollset, {S. E.} and Ueland, {P. M.} and Elshorbagy, {A. K.}",

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Vinknes, KJ, Dekker, JM, Drevon, CA, Refsum, H, Nurk, E, Nijpels, G, Stehouwer, CDA, Teerlink, T, Tell, GS, Nygard, O, Vollset, SE, Ueland, PM & Elshorbagy, AK 2013, 'Plasma sulfur amino acids and stearoyl-CoA desaturase activity in two caucasian populations', Prostaglandins Leukotrienes and Essential Fatty Acids, vol. 89, no. 5, pp. 297-303. https://doi.org/10.1016/j.plefa.2013.09.007

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AU - Dekker, J. M.

AU - Drevon, C. A.

AU - Refsum, H.

AU - Nurk, E.

AU - Nijpels, G.

AU - Stehouwer, C. D. A.

AU - Teerlink, T.

AU - Tell, G. S.

AU - Nygard, O.

AU - Vollset, S. E.

AU - Ueland, P. M.

AU - Elshorbagy, A. K.

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N2 - In rats, dietary restriction of the cysteine precursor methionine suppresses hepatic stearoyl-CoA desaturase (SCD)-1 expression and activity, whereas cysteine supplementation reverses these effects. In 2 independent cohorts: Hordaland Health Study (HUSK; N=2021, aged 71-74 y), Norway, and Hoorn study (N=686, aged 50-87 y), Netherlands, we examined the cross-sectional associations of plasma sulfur-containing compounds (SCC; methionine, S-adenosylmethionine, S-adenosylhomocysteine, homocysteine, cystathionine, total cysteine (tCys), glutathione and cysteinylglycine) with SCD-16 index (16:1n-7/16:0), estimated from fatty acid profiles of total plasma or serum lipids. Only tCys was consistently associated with SCD-16 index after adjustments for sex and age (HUSK: partial r=0.14; Hoorn: partial r=0.11, P

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KW - Cysteine

KW - Sulfur amino acids

KW - Stearoyl-CoA desaturase

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