Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot.

P. Wang, E. Smit, M. Brouwers, G.H. Goossens, C.J.H. van der Kallen, M.M.J. van Greevenbroek, E. Mariman*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Objective: adipose tissue releases factors (adipokines) that influence local, peripheral as well as central processes. In the present study we determined the relationship between plasma concentration of a recently identified adipokine, pigment epithelium-derived factor (PEDF), and human obesity, particularly specific adipose tissue depots, and other features of the metabolic syndrome. Methods: we examined the plasma concentration of PEDF, anthropometric parameters, abdominal subcutaneous and visceral adipose tissue, lipid, glucose, insulin and alanine aminotransferase level in a non-diabetic general Caucasian population (n=59). Results: plasma PEDF level in males (6.2 +/- 2.1 mug/ml) was higher than in females (3.1 +/- 1.4 mug/ml; P<0.001). Plasma PEDF was positively correlated with age and all features of metabolic syndrome. However, in multiple linear regression analysis with adjustment for age and gender, only visceral fat thickness (beta=0.361, P=0.010) and body mass index (BMI) (beta=0.288, P =0.008) were significant independent determinants of plasma PEDF level, together with the gender (beta=-0.424, P<0.001). Conclusions: we conclude that the plasma PEDF level is strongly associated with body adiposity, in particular with the visceral fat depot in the non-diabetic general population. This association may (partly) explain the relationship between PEDF and metabolic syndrome in this population.
Original languageEnglish
Pages (from-to)713-718
JournalEuropean Journal of Endocrinology
Issue number6
Publication statusPublished - 1 Jan 2008

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