Objective: adipose tissue releases factors (adipokines) that influence local, peripheral as well as central processes. In the present study we determined the relationship between plasma concentration of a recently identified adipokine, pigment epithelium-derived factor (PEDF), and human obesity, particularly specific adipose tissue depots, and other features of the metabolic syndrome. Methods: we examined the plasma concentration of PEDF, anthropometric parameters, abdominal subcutaneous and visceral adipose tissue, lipid, glucose, insulin and alanine aminotransferase level in a non-diabetic general Caucasian population (n=59). Results: plasma PEDF level in males (6.2 +/- 2.1 mug/ml) was higher than in females (3.1 +/- 1.4 mug/ml; P<0.001). Plasma PEDF was positively correlated with age and all features of metabolic syndrome. However, in multiple linear regression analysis with adjustment for age and gender, only visceral fat thickness (beta=0.361, P=0.010) and body mass index (BMI) (beta=0.288, P =0.008) were significant independent determinants of plasma PEDF level, together with the gender (beta=-0.424, P<0.001). Conclusions: we conclude that the plasma PEDF level is strongly associated with body adiposity, in particular with the visceral fat depot in the non-diabetic general population. This association may (partly) explain the relationship between PEDF and metabolic syndrome in this population.
Wang, P., Smit, E., Brouwers, M., Goossens, G. H., van der Kallen, C. J. H., van Greevenbroek, M. M. J., & Mariman, E. (2008). Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot. European Journal of Endocrinology, 159(6), 713-718. https://doi.org/10.1530/EJE-08-0521