TY - JOUR
T1 - Plasma pigment epithelium-derived factor is positively associated with obesity in Caucasian subjects, in particular with the visceral fat depot.
AU - Wang, P.
AU - Smit, E.
AU - Brouwers, M.
AU - Goossens, G.H.
AU - van der Kallen, C.J.H.
AU - van Greevenbroek, M.M.J.
AU - Mariman, E.
PY - 2008/1/1
Y1 - 2008/1/1
N2 - Objective: adipose tissue releases factors (adipokines) that influence local, peripheral as well as central processes. In the present study we determined the relationship between plasma concentration of a recently identified adipokine, pigment epithelium-derived factor (PEDF), and human obesity, particularly specific adipose tissue depots, and other features of the metabolic syndrome. Methods: we examined the plasma concentration of PEDF, anthropometric parameters, abdominal subcutaneous and visceral adipose tissue, lipid, glucose, insulin and alanine aminotransferase level in a non-diabetic general Caucasian population (n=59). Results: plasma PEDF level in males (6.2 +/- 2.1 mug/ml) was higher than in females (3.1 +/- 1.4 mug/ml; P<0.001). Plasma PEDF was positively correlated with age and all features of metabolic syndrome. However, in multiple linear regression analysis with adjustment for age and gender, only visceral fat thickness (beta=0.361, P=0.010) and body mass index (BMI) (beta=0.288, P =0.008) were significant independent determinants of plasma PEDF level, together with the gender (beta=-0.424, P<0.001). Conclusions: we conclude that the plasma PEDF level is strongly associated with body adiposity, in particular with the visceral fat depot in the non-diabetic general population. This association may (partly) explain the relationship between PEDF and metabolic syndrome in this population.
AB - Objective: adipose tissue releases factors (adipokines) that influence local, peripheral as well as central processes. In the present study we determined the relationship between plasma concentration of a recently identified adipokine, pigment epithelium-derived factor (PEDF), and human obesity, particularly specific adipose tissue depots, and other features of the metabolic syndrome. Methods: we examined the plasma concentration of PEDF, anthropometric parameters, abdominal subcutaneous and visceral adipose tissue, lipid, glucose, insulin and alanine aminotransferase level in a non-diabetic general Caucasian population (n=59). Results: plasma PEDF level in males (6.2 +/- 2.1 mug/ml) was higher than in females (3.1 +/- 1.4 mug/ml; P<0.001). Plasma PEDF was positively correlated with age and all features of metabolic syndrome. However, in multiple linear regression analysis with adjustment for age and gender, only visceral fat thickness (beta=0.361, P=0.010) and body mass index (BMI) (beta=0.288, P =0.008) were significant independent determinants of plasma PEDF level, together with the gender (beta=-0.424, P<0.001). Conclusions: we conclude that the plasma PEDF level is strongly associated with body adiposity, in particular with the visceral fat depot in the non-diabetic general population. This association may (partly) explain the relationship between PEDF and metabolic syndrome in this population.
U2 - 10.1530/EJE-08-0521
DO - 10.1530/EJE-08-0521
M3 - Article
C2 - 18787046
SN - 0804-4643
VL - 159
SP - 713
EP - 718
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
IS - 6
ER -