Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair

F.A.M.V.I. Hellenthal, J.A. Ten Bosch, B. Pulinx, W.K.W.H. Wodzig, M.W. de Haan, M.H. Prins, R.J.Th.J. Welten, J.A.W. Teijink, G.W.H. Schurink

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

Abstract

OBJECTIVE: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR). REPORT: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak. CONCLUSIONS: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.
Original languageEnglish
Pages (from-to)171-172
Number of pages2
JournalEuropean Journal of Vascular and Endovascular Surgery
Volume43
Issue number2
DOIs
Publication statusPublished - Feb 2012

Keywords

  • Abdominal aortic aneurysm
  • Diagnosis
  • Endoleak
  • MMP-9

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