Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair

F.A.M.V.I. Hellenthal; J.A. Ten Bosch; B. Pulinx; W.K.W.H. Wodzig; M.W. de Haan; M.H. Prins; R.J.Th.J. Welten; J.A.W. Teijink; G.W.H. Schurink

doi:10.1016/j.ejvs.2011.10.014

Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair

F.A.M.V.I. Hellenthal^*, J.A. Ten Bosch, B. Pulinx, W.K.W.H. Wodzig, M.W. de Haan, M.H. Prins, R.J.Th.J. Welten, J.A.W. Teijink, G.W.H. Schurink

^*Corresponding author for this work

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

Abstract

OBJECTIVE: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR). REPORT: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak. CONCLUSIONS: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.

Original language	English
Pages (from-to)	171-172
Number of pages	2
Journal	European Journal of Vascular and Endovascular Surgery
Volume	43
Issue number	2
DOIs	https://doi.org/10.1016/j.ejvs.2011.10.014
Publication status	Published - Feb 2012

Keywords

Abdominal aortic aneurysm
Diagnosis
Endoleak
MMP-9

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Hellenthal, F. A. M. V. I., Ten Bosch, J. A., Pulinx, B., Wodzig, W. K. W. H., de Haan, M. W., Prins, M. H., Welten, R. J. T. J., Teijink, J. A. W., & Schurink, G. W. H. (2012). Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair. European Journal of Vascular and Endovascular Surgery, 43(2), 171-172. https://doi.org/10.1016/j.ejvs.2011.10.014

@article{e7668c7650be44c2a749080d158c029b,

title = "Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair",

abstract = "OBJECTIVE: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR). REPORT: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak. CONCLUSIONS: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.",

keywords = "Abdominal aortic aneurysm, Diagnosis, Endoleak, MMP-9",

author = "F.A.M.V.I. Hellenthal and {Ten Bosch}, J.A. and B. Pulinx and W.K.W.H. Wodzig and {de Haan}, M.W. and M.H. Prins and R.J.Th.J. Welten and J.A.W. Teijink and G.W.H. Schurink",

year = "2012",

month = feb,

doi = "10.1016/j.ejvs.2011.10.014",

language = "English",

volume = "43",

pages = "171--172",

journal = "European Journal of Vascular and Endovascular Surgery",

issn = "1078-5884",

publisher = "Elsevier Saunders",

number = "2",

}

Hellenthal, FAMVI, Ten Bosch, JA, Pulinx, B, Wodzig, WKWH, de Haan, MW, Prins, MH, Welten, RJTJ, Teijink, JAW & Schurink, GWH 2012, 'Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair', European Journal of Vascular and Endovascular Surgery, vol. 43, no. 2, pp. 171-172. https://doi.org/10.1016/j.ejvs.2011.10.014

Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair. / Hellenthal, F.A.M.V.I.; Ten Bosch, J.A.; Pulinx, B. et al.
In: European Journal of Vascular and Endovascular Surgery, Vol. 43, No. 2, 02.2012, p. 171-172.

Research output: Contribution to journal › Comment/Letter to the editor › Academic › peer-review

TY - JOUR

T1 - Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair

AU - Hellenthal, F.A.M.V.I.

AU - Ten Bosch, J.A.

AU - Pulinx, B.

AU - Wodzig, W.K.W.H.

AU - de Haan, M.W.

AU - Prins, M.H.

AU - Welten, R.J.Th.J.

AU - Teijink, J.A.W.

AU - Schurink, G.W.H.

PY - 2012/2

Y1 - 2012/2

N2 - OBJECTIVE: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR). REPORT: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak. CONCLUSIONS: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.

AB - OBJECTIVE: The aim of the study was evaluating the diagnostic value of plasma matrix metalloproteinase- (MMP)-2 and -9 and tissue inhibitor of MMP-1 (TIMP-1) for endoleak detection after endovascular aneurysm repair (EVAR). REPORT: Consecutive EVAR patients (n = 17) with endoleak and matched controls without endoleak (n = 20) were prospectively enrolled. Increased levels of MMP-9 were observed in patients with endoleak (P < 0.001). Regression analysis showed no significant influence of age, sex or abdominal aortic aneurysm (AAA) size. The receiver operating characteristic (ROC) curve of plasma MMP-9 levels showed that a cut-off value of 55.18 ng ml(-1) resulted in 100% sensitivity and 96% specificity with an AUC value of 0.988 (P < 0.001) to detect endoleak. CONCLUSIONS: Plasma MMP-9 levels appear to discriminate between patients with and without an endoleak with high sensitivity and specificity.

KW - Abdominal aortic aneurysm

KW - Diagnosis

KW - Endoleak

KW - MMP-9

U2 - 10.1016/j.ejvs.2011.10.014

DO - 10.1016/j.ejvs.2011.10.014

M3 - Comment/Letter to the editor

C2 - 22172237

SN - 1078-5884

VL - 43

SP - 171

EP - 172

JO - European Journal of Vascular and Endovascular Surgery

JF - European Journal of Vascular and Endovascular Surgery

IS - 2

ER -

Plasma levels of matrix metalloproteinase-9: A possible diagnostic marker of successful endovascular aneurysm repair

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Keywords

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