Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis

T. Hendrikx, S.M. Walenbergh, M. Jeurissen, T. Houben, P.J. van Gorp, P.J. Lindsey, Ger H. Koek, S. Kalhan, J. Pihlajamaki, M.H. Hofker, Ronit Shiri-Sverdlov

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Abstract

AIM: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. MATERIALS & METHODS: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. RESULTS: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. CONCLUSION: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.
Original languageEnglish
Pages (from-to)1301-1309
Number of pages9
JournalBiomarkers in Medicine
Volume9
Issue number12
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • diagnosis
  • hepatic inflammation
  • IL-1Ra
  • NASH
  • FATTY LIVER-DISEASE
  • NAFLD
  • MICE
  • CYTOKERATIN-18
  • OBESITY

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