AIM: Nonalcoholic steatohepatitis (NASH) is a liver disease characterized by lipid accumulation and inflammation. Here, we aimed to evaluate plasma IL-1Ra as a marker for NASH and to determine whether diagnosis of NASH can be further improved by adding IL-1Ra measurements. MATERIALS & METHODS: Therefore, plasma concentrations of IL-1Ra were measured from 146 subjects of a biopsy-proven NASH cohort with matched controls. RESULTS: NASH patients had higher levels of plasma IL-1Ra compared with patients with steatosis or healthy controls. CONCLUSION: Our data confirm that IL-1Ra can be a useful tool in the diagnosis of hepatic inflammation and suggest that measuring plasma IL-1Ra levels in addition to ALT will improve the diagnosis for NASH at all stages of the disease.
- hepatic inflammation
- FATTY LIVER-DISEASE
Hendrikx, T., Walenbergh, S. M., Jeurissen, M., Houben, T., van Gorp, P. J., Lindsey, P. J., Koek, G. H., Kalhan, S., Pihlajamaki, J., Hofker, M. H., & Shiri-Sverdlov, R. (2015). Plasma IL-1 receptor antagonist levels correlate with the development of non-alcoholic steatohepatitis. Biomarkers in Medicine, 9(12), 1301-1309. https://doi.org/10.2217/bmm.15.71