Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients.

D. Hansen, P. Dendale, M. Beelen, R.A. Jonkers, A. Mullens, L. Corluy, R. Meeusen, L.J. van Loon

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Elevated plasma free fatty acid (FFA), inflammatory marker, and altered adipokine concentrations have been observed in obese type 2 diabetes patients. It remains unclear whether these altered plasma concentrations are related to the diabetic state or presence of obesity. In this cross-sectional observational study, we compare basal plasma FFA, inflammatory marker, and adipokine concentrations between obese and non-obese type 2 diabetes patients and healthy, non-obese controls. A total of 20 healthy, normoglycemic males (BMI <30 kg/m(2)), 20 non-obese (BMI <30 kg/m(2)) and 20 obese (BMI >35 kg/m(2)) type 2 diabetes patients were selected to participate in this study. Groups were matched for age and habitual physical activity level. Body composition, glycemic control, and exercise performance capacity were assessed. Basal blood samples were collected to determine plasma leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFalpha), interleukin-6 (IL-6), high-sensitivity C-reactive protein (hsCRP) and FFA concentrations. Plasma FFA, inflammatory marker (hsCRP, IL-6, TNFalpha), adipokine (adiponectin, resistin, leptin), and triglyceride concentrations did not differ between non-obese diabetes patients and healthy, normoglycemic controls. Plasma FFA, IL-6, hsCRP, leptin, and triglyceride levels were significantly higher in the obese diabetes patients when compared with the healthy normoglycemic controls (P < 0.05). Furthermore, plasma hsCRP and leptin levels were significantly higher in the obese versus non-obese diabetes patients (P < 0.05). Significant correlations between plasma parameters and glycemic control were observed, but disappeared after adjusting for trunk adipose tissue mass. Elevated plasma leptin, hsCRP, IL-6, and FFA concentrations are associated with obesity and not necessarily with the type 2 diabetic state.
Original languageEnglish
Pages (from-to)397-404
Number of pages8
JournalEuropean Journal of Applied Physiology
Volume109
Issue number3
DOIs
Publication statusPublished - Jun 2010

Keywords

  • Obesity
  • Diabetes
  • Adipokines
  • Inflammation
  • Fat mass
  • NECROSIS-FACTOR-ALPHA
  • C-REACTIVE PROTEIN
  • ASIAN INDIAN MEN
  • INSULIN-RESISTANCE
  • ADIPOSE-TISSUE
  • SERUM RESISTIN
  • LEPTIN LEVELS
  • BODY-FAT
  • METABOLIC COMPLICATIONS
  • ADIPONECTIN LEVELS

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