Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques

M. T. Truijman, M.E. Kooi, A.C. van Dijk, A.A. de Rotte, A.G. van der Kolk, M.I. Liem, F.H. Schreuder, E. Boersma, W.H. Mess, R.J. van Oostenbrugge, P.J. Koudstaal, L.J. Kappelle, P.J. Nederkoorn, A.J. Nederveen, J. Hendrikse, A.F. van der Steen, M.J. Daemen, A. van der Lugt

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Abstract

BACKGROUND: Patients with symptomatic carotid artery stenosis are at high risk for recurrent stroke. To date, the decision to perform carotid endarterectomy in patients with a recent cerebrovascular event is mainly based on degree of stenosis of the ipsilateral carotid artery. However, additional atherosclerotic plaque characteristics might be better predictors of stroke, allowing for more precise selection of patients for carotid endarterectomy. AIMS AND HYPOTHESIS: We investigate the hypothesis that the assessment of carotid plaque characteristics with magnetic resonance imaging, multidetector-row computed tomography angiography, ultrasonography, and transcranial Doppler, either alone or in combination, may improve identification of a subgroup of patients with < 70% carotid artery stenosis with an increased risk of recurrent stroke. METHODS: The Plaque At RISK (PARISK) study is a prospective multicenter cohort study of patients with recent (<3 months) neurological symptoms due to ischemia in the territory of the carotid artery and < 70% ipsilateral carotid artery stenosis who are not scheduled for carotid endarterectomy or stenting. At baseline, 300 patients will undergo magnetic resonance imaging, multidetector-row computed tomography angiography, and ultrasonography examination of the carotid arteries. In addition, magnetic resonance imaging of the brain, ambulatory transcranial Doppler recording of the middle cerebral artery and blood withdrawal will be performed. After two-years, imaging will be repeated in 150 patients. All patients undergo a follow-up brain magnetic resonance imaging, and there will be regular clinical follow-up until the end of the study. STUDY OUTCOMES: The combined primary end-point contains ipsilateral recurrent ischemic stroke or transient ischemic attack or new ipsilateral ischemic brain lesions on follow-up brain magnetic resonance imaging.
Original languageEnglish
Pages (from-to)747-754
Number of pages8
JournalInternational journal of stroke
Volume9
Issue number6
DOIs
Publication statusPublished - Aug 2014

Keywords

  • atherosclerosis
  • CT
  • stroke
  • MRI
  • prospective
  • ultrasound
  • RICH NECROTIC CORE
  • ATHEROSCLEROTIC PLAQUE
  • COMPUTED-TOMOGRAPHY
  • ARTERY STENOSIS
  • FIBROUS CAP
  • STROKE
  • ENDARTERECTOMY
  • TRIAL
  • ABNORMALITIES

Cite this

Truijman, M. T., Kooi, M. E., van Dijk, A. C., de Rotte, A. A., van der Kolk, A. G., Liem, M. I., ... van der Lugt, A. (2014). Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques. International journal of stroke, 9(6), 747-754. https://doi.org/10.1111/ijs.12167
Truijman, M. T. ; Kooi, M.E. ; van Dijk, A.C. ; de Rotte, A.A. ; van der Kolk, A.G. ; Liem, M.I. ; Schreuder, F.H. ; Boersma, E. ; Mess, W.H. ; van Oostenbrugge, R.J. ; Koudstaal, P.J. ; Kappelle, L.J. ; Nederkoorn, P.J. ; Nederveen, A.J. ; Hendrikse, J. ; van der Steen, A.F. ; Daemen, M.J. ; van der Lugt, A. / Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques. In: International journal of stroke. 2014 ; Vol. 9, No. 6. pp. 747-754.
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title = "Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques",
abstract = "BACKGROUND: Patients with symptomatic carotid artery stenosis are at high risk for recurrent stroke. To date, the decision to perform carotid endarterectomy in patients with a recent cerebrovascular event is mainly based on degree of stenosis of the ipsilateral carotid artery. However, additional atherosclerotic plaque characteristics might be better predictors of stroke, allowing for more precise selection of patients for carotid endarterectomy. AIMS AND HYPOTHESIS: We investigate the hypothesis that the assessment of carotid plaque characteristics with magnetic resonance imaging, multidetector-row computed tomography angiography, ultrasonography, and transcranial Doppler, either alone or in combination, may improve identification of a subgroup of patients with < 70{\%} carotid artery stenosis with an increased risk of recurrent stroke. METHODS: The Plaque At RISK (PARISK) study is a prospective multicenter cohort study of patients with recent (<3 months) neurological symptoms due to ischemia in the territory of the carotid artery and < 70{\%} ipsilateral carotid artery stenosis who are not scheduled for carotid endarterectomy or stenting. At baseline, 300 patients will undergo magnetic resonance imaging, multidetector-row computed tomography angiography, and ultrasonography examination of the carotid arteries. In addition, magnetic resonance imaging of the brain, ambulatory transcranial Doppler recording of the middle cerebral artery and blood withdrawal will be performed. After two-years, imaging will be repeated in 150 patients. All patients undergo a follow-up brain magnetic resonance imaging, and there will be regular clinical follow-up until the end of the study. STUDY OUTCOMES: The combined primary end-point contains ipsilateral recurrent ischemic stroke or transient ischemic attack or new ipsilateral ischemic brain lesions on follow-up brain magnetic resonance imaging.",
keywords = "atherosclerosis, CT, stroke, MRI, prospective, ultrasound, RICH NECROTIC CORE, ATHEROSCLEROTIC PLAQUE, COMPUTED-TOMOGRAPHY, ARTERY STENOSIS, FIBROUS CAP, STROKE, ENDARTERECTOMY, TRIAL, ABNORMALITIES",
author = "Truijman, {M. T.} and M.E. Kooi and {van Dijk}, A.C. and {de Rotte}, A.A. and {van der Kolk}, A.G. and M.I. Liem and F.H. Schreuder and E. Boersma and W.H. Mess and {van Oostenbrugge}, R.J. and P.J. Koudstaal and L.J. Kappelle and P.J. Nederkoorn and A.J. Nederveen and J. Hendrikse and {van der Steen}, A.F. and M.J. Daemen and {van der Lugt}, A.",
year = "2014",
month = "8",
doi = "10.1111/ijs.12167",
language = "English",
volume = "9",
pages = "747--754",
journal = "International journal of stroke",
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Truijman, MT, Kooi, ME, van Dijk, AC, de Rotte, AA, van der Kolk, AG, Liem, MI, Schreuder, FH, Boersma, E, Mess, WH, van Oostenbrugge, RJ, Koudstaal, PJ, Kappelle, LJ, Nederkoorn, PJ, Nederveen, AJ, Hendrikse, J, van der Steen, AF, Daemen, MJ & van der Lugt, A 2014, 'Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques', International journal of stroke, vol. 9, no. 6, pp. 747-754. https://doi.org/10.1111/ijs.12167

Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques. / Truijman, M. T.; Kooi, M.E.; van Dijk, A.C.; de Rotte, A.A.; van der Kolk, A.G.; Liem, M.I.; Schreuder, F.H.; Boersma, E.; Mess, W.H.; van Oostenbrugge, R.J.; Koudstaal, P.J.; Kappelle, L.J.; Nederkoorn, P.J.; Nederveen, A.J.; Hendrikse, J.; van der Steen, A.F.; Daemen, M.J.; van der Lugt, A.

In: International journal of stroke, Vol. 9, No. 6, 08.2014, p. 747-754.

Research output: Contribution to journalArticleAcademicpeer-review

TY - JOUR

T1 - Plaque At RISK (PARISK): prospective multicenter study to improve diagnosis of high-risk carotid plaques

AU - Truijman, M. T.

AU - Kooi, M.E.

AU - van Dijk, A.C.

AU - de Rotte, A.A.

AU - van der Kolk, A.G.

AU - Liem, M.I.

AU - Schreuder, F.H.

AU - Boersma, E.

AU - Mess, W.H.

AU - van Oostenbrugge, R.J.

AU - Koudstaal, P.J.

AU - Kappelle, L.J.

AU - Nederkoorn, P.J.

AU - Nederveen, A.J.

AU - Hendrikse, J.

AU - van der Steen, A.F.

AU - Daemen, M.J.

AU - van der Lugt, A.

PY - 2014/8

Y1 - 2014/8

N2 - BACKGROUND: Patients with symptomatic carotid artery stenosis are at high risk for recurrent stroke. To date, the decision to perform carotid endarterectomy in patients with a recent cerebrovascular event is mainly based on degree of stenosis of the ipsilateral carotid artery. However, additional atherosclerotic plaque characteristics might be better predictors of stroke, allowing for more precise selection of patients for carotid endarterectomy. AIMS AND HYPOTHESIS: We investigate the hypothesis that the assessment of carotid plaque characteristics with magnetic resonance imaging, multidetector-row computed tomography angiography, ultrasonography, and transcranial Doppler, either alone or in combination, may improve identification of a subgroup of patients with < 70% carotid artery stenosis with an increased risk of recurrent stroke. METHODS: The Plaque At RISK (PARISK) study is a prospective multicenter cohort study of patients with recent (<3 months) neurological symptoms due to ischemia in the territory of the carotid artery and < 70% ipsilateral carotid artery stenosis who are not scheduled for carotid endarterectomy or stenting. At baseline, 300 patients will undergo magnetic resonance imaging, multidetector-row computed tomography angiography, and ultrasonography examination of the carotid arteries. In addition, magnetic resonance imaging of the brain, ambulatory transcranial Doppler recording of the middle cerebral artery and blood withdrawal will be performed. After two-years, imaging will be repeated in 150 patients. All patients undergo a follow-up brain magnetic resonance imaging, and there will be regular clinical follow-up until the end of the study. STUDY OUTCOMES: The combined primary end-point contains ipsilateral recurrent ischemic stroke or transient ischemic attack or new ipsilateral ischemic brain lesions on follow-up brain magnetic resonance imaging.

AB - BACKGROUND: Patients with symptomatic carotid artery stenosis are at high risk for recurrent stroke. To date, the decision to perform carotid endarterectomy in patients with a recent cerebrovascular event is mainly based on degree of stenosis of the ipsilateral carotid artery. However, additional atherosclerotic plaque characteristics might be better predictors of stroke, allowing for more precise selection of patients for carotid endarterectomy. AIMS AND HYPOTHESIS: We investigate the hypothesis that the assessment of carotid plaque characteristics with magnetic resonance imaging, multidetector-row computed tomography angiography, ultrasonography, and transcranial Doppler, either alone or in combination, may improve identification of a subgroup of patients with < 70% carotid artery stenosis with an increased risk of recurrent stroke. METHODS: The Plaque At RISK (PARISK) study is a prospective multicenter cohort study of patients with recent (<3 months) neurological symptoms due to ischemia in the territory of the carotid artery and < 70% ipsilateral carotid artery stenosis who are not scheduled for carotid endarterectomy or stenting. At baseline, 300 patients will undergo magnetic resonance imaging, multidetector-row computed tomography angiography, and ultrasonography examination of the carotid arteries. In addition, magnetic resonance imaging of the brain, ambulatory transcranial Doppler recording of the middle cerebral artery and blood withdrawal will be performed. After two-years, imaging will be repeated in 150 patients. All patients undergo a follow-up brain magnetic resonance imaging, and there will be regular clinical follow-up until the end of the study. STUDY OUTCOMES: The combined primary end-point contains ipsilateral recurrent ischemic stroke or transient ischemic attack or new ipsilateral ischemic brain lesions on follow-up brain magnetic resonance imaging.

KW - atherosclerosis

KW - CT

KW - stroke

KW - MRI

KW - prospective

KW - ultrasound

KW - RICH NECROTIC CORE

KW - ATHEROSCLEROTIC PLAQUE

KW - COMPUTED-TOMOGRAPHY

KW - ARTERY STENOSIS

KW - FIBROUS CAP

KW - STROKE

KW - ENDARTERECTOMY

KW - TRIAL

KW - ABNORMALITIES

U2 - 10.1111/ijs.12167

DO - 10.1111/ijs.12167

M3 - Article

VL - 9

SP - 747

EP - 754

JO - International journal of stroke

JF - International journal of stroke

SN - 1747-4930

IS - 6

ER -