Plant-Derived Extracellular Vesicles: Current Findings, Challenges, and Future Applications

N. Kameli, A. Dragojlovic-Kerkache, P. Savelkoul, F.R. Stassen*

*Corresponding author for this work

Research output: Contribution to journal(Systematic) Review article peer-review

14 Citations (Web of Science)

Abstract

In recent years, plant-derived extracellular vesicles (PDEVs) have gained the interest of many experts in fields such as microbiology and immunology, and research in this field has exponentially increased. These nano-sized particles have provided researchers with a number of interesting findings, making their application in human health and disease very promising. Both in vitro and in vivo experiments have shown that PDEVs can exhibit a multitude of effects, suggesting that these vesicles may have many potential future applications, including therapeutics and nano-delivery of compounds. While the preliminary results are promising, there are still some challenges to face, such as a lack of protocol standardization, as well as knowledge gaps that need to be filled. This review aims to discuss various aspects of PDEV knowledge, including their preliminary findings, challenges, and future uses, giving insight into the complexity of conducting research in this field.
Original languageEnglish
Article number411
Number of pages9
JournalMembranes
Volume11
Issue number6
DOIs
Publication statusPublished - 1 Jun 2021

Keywords

  • extracellular vesicles
  • plant EVs
  • intestinal homeostasis
  • immunomodulatory effects
  • therapeutic applications
  • DRUG-DELIVERY
  • THERAPEUTIC AGENTS
  • NANOPARTICLES
  • MICRORNAS
  • EXOSOMES
  • COLITIS
  • DISEASE
  • IMPACT
  • CELLS

Cite this