Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Jos Prickaerts, Nick P. Van Goethem, Walter Gulisano, Elentina K. Argyrousi, Agostino Palmeri, Daniela Puzzo*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)59-70
Number of pages12
JournalEuropean Journal of Pharmacology
Volume817
DOIs
Publication statusPublished - 15 Dec 2017

Keywords

  • Dose-response curves
  • Synaptic plasticity
  • Memory
  • Alzheimer's disease
  • Cognitive-enhancing drugs
  • Low doses
  • NITRIC-OXIDE SYNTHASE
  • NICOTINIC ACETYLCHOLINE-RECEPTORS
  • LONG-TERM POTENTIATION
  • OBJECT RECOGNITION MEMORY
  • CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES
  • RANDOMIZED CONTROLLED-TRIAL
  • CENTRAL-NERVOUS-SYSTEM
  • CEREBRAL-BLOOD-FLOW
  • PROTEIN-KINASE-A
  • LATE-PHASE LTP

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