Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Jos Prickaerts; Nick P. Van Goethem; Walter Gulisano; Elentina K. Argyrousi; Agostino Palmeri; Daniela Puzzo

doi:10.1016/j.ejphar.2017.05.058

Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve

Jos Prickaerts, Nick P. Van Goethem, Walter Gulisano, Elentina K. Argyrousi, Agostino Palmeri, Daniela Puzzo^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	59-70
Number of pages	12
Journal	European Journal of Pharmacology
Volume	817
DOIs	https://doi.org/10.1016/j.ejphar.2017.05.058
Publication status	Published - 15 Dec 2017

Keywords

Dose-response curves
Synaptic plasticity
Memory
Alzheimer's disease
Cognitive-enhancing drugs
Low doses
NITRIC-OXIDE SYNTHASE
NICOTINIC ACETYLCHOLINE-RECEPTORS
LONG-TERM POTENTIATION
OBJECT RECOGNITION MEMORY
CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES
RANDOMIZED CONTROLLED-TRIAL
CENTRAL-NERVOUS-SYSTEM
CEREBRAL-BLOOD-FLOW
PROTEIN-KINASE-A
LATE-PHASE LTP

Access to Document

10.1016/j.ejphar.2017.05.058

Cite this

Prickaerts, J., Van Goethem, N. P., Gulisano, W., Argyrousi, E. K., Palmeri, A., & Puzzo, D. (2017). Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve. European Journal of Pharmacology, 817, 59-70. https://doi.org/10.1016/j.ejphar.2017.05.058

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title = "Physiological and pathological processes of synaptic plasticity and memory in drug discovery: Do not forget the dose-response curve",

keywords = "Dose-response curves, Synaptic plasticity, Memory, Alzheimer's disease, Cognitive-enhancing drugs, Low doses, NITRIC-OXIDE SYNTHASE, NICOTINIC ACETYLCHOLINE-RECEPTORS, LONG-TERM POTENTIATION, OBJECT RECOGNITION MEMORY, CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES, RANDOMIZED CONTROLLED-TRIAL, CENTRAL-NERVOUS-SYSTEM, CEREBRAL-BLOOD-FLOW, PROTEIN-KINASE-A, LATE-PHASE LTP",

author = "Jos Prickaerts and {Van Goethem}, {Nick P.} and Walter Gulisano and Argyrousi, {Elentina K.} and Agostino Palmeri and Daniela Puzzo",

year = "2017",

month = dec,

day = "15",

doi = "10.1016/j.ejphar.2017.05.058",

language = "English",

volume = "817",

pages = "59--70",

journal = "European Journal of Pharmacology",

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Physiological and pathological processes of synaptic plasticity and memory in drug discovery : Do not forget the dose-response curve. / Prickaerts, Jos; Van Goethem, Nick P.; Gulisano, Walter; Argyrousi, Elentina K.; Palmeri, Agostino; Puzzo, Daniela.

In: European Journal of Pharmacology, Vol. 817, 15.12.2017, p. 59-70.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Physiological and pathological processes of synaptic plasticity and memory in drug discovery

T2 - Do not forget the dose-response curve

AU - Prickaerts, Jos

AU - Van Goethem, Nick P.

AU - Gulisano, Walter

AU - Argyrousi, Elentina K.

AU - Palmeri, Agostino

AU - Puzzo, Daniela

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KW - Memory

KW - Alzheimer's disease

KW - Cognitive-enhancing drugs

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KW - LONG-TERM POTENTIATION

KW - OBJECT RECOGNITION MEMORY

KW - CYCLIC-NUCLEOTIDE PHOSPHODIESTERASES

KW - RANDOMIZED CONTROLLED-TRIAL

KW - CENTRAL-NERVOUS-SYSTEM

KW - CEREBRAL-BLOOD-FLOW

KW - PROTEIN-KINASE-A

KW - LATE-PHASE LTP

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DO - 10.1016/j.ejphar.2017.05.058

M3 - Article

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EP - 70

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

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