Physical Activity, Occupational Sitting Time, and Colorectal Cancer Risk in the Netherlands Cohort Study

Colinda C. J. M. Simons*, Laura A. E. Hughes, Manon van Engeland, R. Alexandra Goldbohm, Piet A. van den Brandt, Matty P. Weijenberg

*Corresponding author for this work

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We investigated occupational energy expenditure and sitting time in the longest held job (in men only), nonoccupational physical activity, and former sports participation in relation to colorectal cancer endpoints. The Netherlands Cohort Study includes 120,852 participants who completed a self-administered questionnaire in 1986 when they were aged 55-69 years. By 2002, 1,819 male and 1,366 female colorectal cancer cases were available for case-cohort analyses. In men, higher occupational energy expenditure levels and fewer occupational sitting hours were associated with decreased hazard ratios for colon cancer, particularly distal colon cancer (occupational energy expenditure of >= 12 vs. 90 vs. 90 vs.
Original languageEnglish
Pages (from-to)514-530
JournalAmerican Journal of Epidemiology
Issue number6
Publication statusPublished - 15 Mar 2013


  • cohort studies
  • colonic neoplasms
  • physical activity
  • rectal neoplasms
  • sedentary lifestyle

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