Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer

Karel C Smit; Jeroen W G Derksen; Geerard L O Beets; Eric J Th Belt; Maaike Berbee; Peter Paul L O Coene; Hester van Cruijsen; Marjan A Davidis; Jan Willem T Dekker; Joyce M van Dodewaard-de Jong; Annebeth W Haringhuizen; Helgi H Helgason; Mathijs P Hendriks; Ronald Hoekstra; Ignace H J T de Hingh; Jan N M IJzermans; Johan J B Janssen; Joop L M Konsten; Maartje Los; Leonie J M Mekenkamp; Peter Nieboer; Koen C M J Peeters; Natascha A J B Peters; Hans J F M Pruijt; Patricia Quarles van Ufford-Mannesse; Ron C Rietbroek; Anandi H W Schiphorst; Arjan Schouten van der Velden; Ruud W M Schrauwen; Mark P S Sie; Dirkje W Sommeijer; Dirk J A Sonneveld; Hein B A C Stockmann; Marleen Tent; Frederiek Terheggen; Manuel L R Tjin-A-Ton; Liselot Valkenburg-van Iersel; Ankie M T van der Velden; Wouter J Vles; Theo van Voorthuizen; Johannes A Wegdam; Johannes H W de Wilt; Miriam Koopman; Anne M May; null On Behalf Of The Plcrc Study Group

doi:10.3390/cancers14041001

Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer

Karel C Smit, Jeroen W G Derksen, Geerard L O Beets, Eric J Th Belt, Maaike Berbee, Peter Paul L O Coene, Hester van Cruijsen, Marjan A Davidis, Jan Willem T Dekker, Joyce M van Dodewaard-de Jong, Annebeth W Haringhuizen, Helgi H Helgason, Mathijs P Hendriks, Ronald Hoekstra, Ignace H J T de Hingh, Jan N M IJzermans, Johan J B Janssen, Joop L M Konsten, Maartje Los, Leonie J M MekenkampPeter Nieboer, Koen C M J Peeters, Natascha A J B Peters, Hans J F M Pruijt, Patricia Quarles van Ufford-Mannesse, Ron C Rietbroek, Anandi H W Schiphorst, Arjan Schouten van der Velden, Ruud W M Schrauwen, Mark P S Sie, Dirkje W Sommeijer, Dirk J A Sonneveld, Hein B A C Stockmann, Marleen Tent, Frederiek Terheggen, Manuel L R Tjin-A-Ton, Liselot Valkenburg-van Iersel, Ankie M T van der Velden, Wouter J Vles, Theo van Voorthuizen, Johannes A Wegdam, Johannes H W de Wilt, Miriam Koopman, Anne M May^*, On Behalf Of The Plcrc Study Group

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort. PA was assessed with the validated SQUASH questionnaire, filled-in within a maximum of 60 days after diagnosis of mCRC. PA was quantified by calculating Metabolic Equivalent Task (MET) hours per week. American College of Sports and Medicine (ACSM) PA guideline adherence, tertiles of moderate to vigorous PA (MVPA), and sport and leisure time MVPA (MVPA-SL) were assessed as well. Vital status was obtained from the municipal population registry. Cox proportional-hazards models were used to study the association between PA determinants and all-cause mortality adjusted for prognostic patient and treatment-related factors. In total, 293 mCRC patients (mean age 62.9 ± 10.6 years, 67% male) were included in the analysis. Compared to low levels, moderate and high levels of MET-hours were significantly associated with longer OS (fully adjusted hazard ratios: 0.491, (95% CI 0.299-0.807, p value = 0.005) and 0.485 (95% CI 0.303-0.778, p value = 0.003), respectively), as were high levels of MVPA (0.476 (95% CI 0.278-0.816, p value = 0.007)) and MVPA-SL (0.389 (95% CI 0.224-0.677, p value < 0.001)), and adherence to ACSM PA guidelines compared to non-adherence (0.629 (95% CI 0.412-0.961, p value = 0.032)). The present study provides evidence that higher PA levels at diagnosis of mCRC are associated with longer OS.

Original language	English
Article number	1001
Number of pages	14
Journal	Cancers
Volume	14
Issue number	4
DOIs	https://doi.org/10.3390/cancers14041001
Publication status	Published - 16 Feb 2022

Keywords

BODY-MASS INDEX
BREAST
DIAGNOSIS
EXERCISE
FATIGUE
METAANALYSIS
MORTALITY
NUTRITION
REPRODUCIBILITY
VALIDITY
all-cause mortality
metastatic colorectal cancer
physical activity
survival
COHORT

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Smit, K. C., Derksen, J. W. G., Beets, G. L. O., Belt, E. J. T., Berbee, M., Coene, P. P. L. O., van Cruijsen, H., Davidis, M. A., Dekker, J. W. T., van Dodewaard-de Jong, J. M., Haringhuizen, A. W., Helgason, H. H., Hendriks, M. P., Hoekstra, R., de Hingh, I. H. J. T., IJzermans, J. N. M., Janssen, J. J. B., Konsten, J. L. M., Los, M., ... On Behalf Of The Plcrc Study Group (2022). Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer. Cancers, 14(4), Article 1001. https://doi.org/10.3390/cancers14041001

@article{923687fbb955448e922699dba129b4dd,

title = "Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer",

abstract = "Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort. PA was assessed with the validated SQUASH questionnaire, filled-in within a maximum of 60 days after diagnosis of mCRC. PA was quantified by calculating Metabolic Equivalent Task (MET) hours per week. American College of Sports and Medicine (ACSM) PA guideline adherence, tertiles of moderate to vigorous PA (MVPA), and sport and leisure time MVPA (MVPA-SL) were assessed as well. Vital status was obtained from the municipal population registry. Cox proportional-hazards models were used to study the association between PA determinants and all-cause mortality adjusted for prognostic patient and treatment-related factors. In total, 293 mCRC patients (mean age 62.9 ± 10.6 years, 67% male) were included in the analysis. Compared to low levels, moderate and high levels of MET-hours were significantly associated with longer OS (fully adjusted hazard ratios: 0.491, (95% CI 0.299-0.807, p value = 0.005) and 0.485 (95% CI 0.303-0.778, p value = 0.003), respectively), as were high levels of MVPA (0.476 (95% CI 0.278-0.816, p value = 0.007)) and MVPA-SL (0.389 (95% CI 0.224-0.677, p value < 0.001)), and adherence to ACSM PA guidelines compared to non-adherence (0.629 (95% CI 0.412-0.961, p value = 0.032)). The present study provides evidence that higher PA levels at diagnosis of mCRC are associated with longer OS.",

keywords = "BODY-MASS INDEX, BREAST, DIAGNOSIS, EXERCISE, FATIGUE, METAANALYSIS, MORTALITY, NUTRITION, REPRODUCIBILITY, VALIDITY, all-cause mortality, metastatic colorectal cancer, physical activity, survival, COHORT",

author = "Smit, {Karel C} and Derksen, {Jeroen W G} and Beets, {Geerard L O} and Belt, {Eric J Th} and Maaike Berbee and Coene, {Peter Paul L O} and {van Cruijsen}, Hester and Davidis, {Marjan A} and Dekker, {Jan Willem T} and {van Dodewaard-de Jong}, {Joyce M} and Haringhuizen, {Annebeth W} and Helgason, {Helgi H} and Hendriks, {Mathijs P} and Ronald Hoekstra and {de Hingh}, {Ignace H J T} and IJzermans, {Jan N M} and Janssen, {Johan J B} and Konsten, {Joop L M} and Maartje Los and Mekenkamp, {Leonie J M} and Peter Nieboer and Peeters, {Koen C M J} and Peters, {Natascha A J B} and Pruijt, {Hans J F M} and {Quarles van Ufford-Mannesse}, Patricia and Rietbroek, {Ron C} and Schiphorst, {Anandi H W} and {Schouten van der Velden}, Arjan and Schrauwen, {Ruud W M} and Sie, {Mark P S} and Sommeijer, {Dirkje W} and Sonneveld, {Dirk J A} and Stockmann, {Hein B A C} and Marleen Tent and Frederiek Terheggen and Tjin-A-Ton, {Manuel L R} and {Valkenburg-van Iersel}, Liselot and {van der Velden}, {Ankie M T} and Vles, {Wouter J} and {van Voorthuizen}, Theo and Wegdam, {Johannes A} and {de Wilt}, {Johannes H W} and Miriam Koopman and May, {Anne M} and {On Behalf Of The Plcrc Study Group}",

year = "2022",

month = feb,

day = "16",

doi = "10.3390/cancers14041001",

language = "English",

volume = "14",

journal = "Cancers",

issn = "2072-6694",

publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",

number = "4",

}

Smit, KC, Derksen, JWG, Beets, GLO, Belt, EJT, Berbee, M, Coene, PPLO, van Cruijsen, H, Davidis, MA, Dekker, JWT, van Dodewaard-de Jong, JM, Haringhuizen, AW, Helgason, HH, Hendriks, MP, Hoekstra, R, de Hingh, IHJT, IJzermans, JNM, Janssen, JJB, Konsten, JLM, Los, M, Mekenkamp, LJM, Nieboer, P, Peeters, KCMJ, Peters, NAJB, Pruijt, HJFM, Quarles van Ufford-Mannesse, P, Rietbroek, RC, Schiphorst, AHW, Schouten van der Velden, A, Schrauwen, RWM, Sie, MPS, Sommeijer, DW, Sonneveld, DJA, Stockmann, HBAC, Tent, M, Terheggen, F, Tjin-A-Ton, MLR, Valkenburg-van Iersel, L, van der Velden, AMT, Vles, WJ, van Voorthuizen, T, Wegdam, JA, de Wilt, JHW, Koopman, M, May, AM & On Behalf Of The Plcrc Study Group 2022, 'Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer', Cancers, vol. 14, no. 4, 1001. https://doi.org/10.3390/cancers14041001

TY - JOUR

T1 - Physical Activity Is Associated with Improved Overall Survival among Patients with Metastatic Colorectal Cancer

AU - Smit, Karel C

AU - Derksen, Jeroen W G

AU - Beets, Geerard L O

AU - Belt, Eric J Th

AU - Berbee, Maaike

AU - Coene, Peter Paul L O

AU - van Cruijsen, Hester

AU - Davidis, Marjan A

AU - Dekker, Jan Willem T

AU - van Dodewaard-de Jong, Joyce M

AU - Haringhuizen, Annebeth W

AU - Helgason, Helgi H

AU - Hendriks, Mathijs P

AU - Hoekstra, Ronald

AU - de Hingh, Ignace H J T

AU - IJzermans, Jan N M

AU - Janssen, Johan J B

AU - Konsten, Joop L M

AU - Los, Maartje

AU - Mekenkamp, Leonie J M

AU - Nieboer, Peter

AU - Peeters, Koen C M J

AU - Peters, Natascha A J B

AU - Pruijt, Hans J F M

AU - Quarles van Ufford-Mannesse, Patricia

AU - Rietbroek, Ron C

AU - Schiphorst, Anandi H W

AU - Schouten van der Velden, Arjan

AU - Schrauwen, Ruud W M

AU - Sie, Mark P S

AU - Sommeijer, Dirkje W

AU - Sonneveld, Dirk J A

AU - Stockmann, Hein B A C

AU - Tent, Marleen

AU - Terheggen, Frederiek

AU - Tjin-A-Ton, Manuel L R

AU - Valkenburg-van Iersel, Liselot

AU - van der Velden, Ankie M T

AU - Vles, Wouter J

AU - van Voorthuizen, Theo

AU - Wegdam, Johannes A

AU - de Wilt, Johannes H W

AU - Koopman, Miriam

AU - May, Anne M

AU - On Behalf Of The Plcrc Study Group, null

PY - 2022/2/16

Y1 - 2022/2/16

N2 - Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort. PA was assessed with the validated SQUASH questionnaire, filled-in within a maximum of 60 days after diagnosis of mCRC. PA was quantified by calculating Metabolic Equivalent Task (MET) hours per week. American College of Sports and Medicine (ACSM) PA guideline adherence, tertiles of moderate to vigorous PA (MVPA), and sport and leisure time MVPA (MVPA-SL) were assessed as well. Vital status was obtained from the municipal population registry. Cox proportional-hazards models were used to study the association between PA determinants and all-cause mortality adjusted for prognostic patient and treatment-related factors. In total, 293 mCRC patients (mean age 62.9 ± 10.6 years, 67% male) were included in the analysis. Compared to low levels, moderate and high levels of MET-hours were significantly associated with longer OS (fully adjusted hazard ratios: 0.491, (95% CI 0.299-0.807, p value = 0.005) and 0.485 (95% CI 0.303-0.778, p value = 0.003), respectively), as were high levels of MVPA (0.476 (95% CI 0.278-0.816, p value = 0.007)) and MVPA-SL (0.389 (95% CI 0.224-0.677, p value < 0.001)), and adherence to ACSM PA guidelines compared to non-adherence (0.629 (95% CI 0.412-0.961, p value = 0.032)). The present study provides evidence that higher PA levels at diagnosis of mCRC are associated with longer OS.

AB - Regular physical activity (PA) is associated with improved overall survival (OS) in stage I-III colorectal cancer (CRC) patients. This association is less defined in patients with metastatic CRC (mCRC). We therefore conducted a study in mCRC patients participating in the Prospective Dutch Colorectal Cancer cohort. PA was assessed with the validated SQUASH questionnaire, filled-in within a maximum of 60 days after diagnosis of mCRC. PA was quantified by calculating Metabolic Equivalent Task (MET) hours per week. American College of Sports and Medicine (ACSM) PA guideline adherence, tertiles of moderate to vigorous PA (MVPA), and sport and leisure time MVPA (MVPA-SL) were assessed as well. Vital status was obtained from the municipal population registry. Cox proportional-hazards models were used to study the association between PA determinants and all-cause mortality adjusted for prognostic patient and treatment-related factors. In total, 293 mCRC patients (mean age 62.9 ± 10.6 years, 67% male) were included in the analysis. Compared to low levels, moderate and high levels of MET-hours were significantly associated with longer OS (fully adjusted hazard ratios: 0.491, (95% CI 0.299-0.807, p value = 0.005) and 0.485 (95% CI 0.303-0.778, p value = 0.003), respectively), as were high levels of MVPA (0.476 (95% CI 0.278-0.816, p value = 0.007)) and MVPA-SL (0.389 (95% CI 0.224-0.677, p value < 0.001)), and adherence to ACSM PA guidelines compared to non-adherence (0.629 (95% CI 0.412-0.961, p value = 0.032)). The present study provides evidence that higher PA levels at diagnosis of mCRC are associated with longer OS.

KW - BODY-MASS INDEX

KW - BREAST

KW - DIAGNOSIS

KW - EXERCISE

KW - FATIGUE

KW - METAANALYSIS

KW - MORTALITY

KW - NUTRITION

KW - REPRODUCIBILITY

KW - VALIDITY

KW - all-cause mortality

KW - metastatic colorectal cancer

KW - physical activity

KW - survival

KW - COHORT

U2 - 10.3390/cancers14041001

DO - 10.3390/cancers14041001

M3 - Article

C2 - 35205748

SN - 2072-6694

VL - 14

JO - Cancers

JF - Cancers

IS - 4

M1 - 1001

ER -