Physical Activity in End-Stage Renal Disease Patients: The Effects of Starting Dialysis in the First 6 Months after the Transition Period

Natascha J. H. Broers*, Remy J. H. Martens, Tom Cornelis, Frank M. van der Sande, Nanda M. P. Diederen, Marc M. H. Hermans, Joris J. J. M. Wirtz, Frank Stifft, Constantijn J. A. M. Konings, Tom Dejagere, Bernard Canaud, Peter Wabel, Karel M. L. Leunissen, Jeroen P. Kooman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

30 Citations (Web of Science)

Abstract

Objectives: Physical inactivity in end-stage renal disease (ESRD) patients is associated with increased mortality, and might be related to abnormalities in body composition (BC) and physical performance. It is uncertain to what extent starting dialysis influences the effects of ESRD on physical activity (PA). This study aimed to compare PA and physical performance between stage 5 chronic kidney disease (CKD-5) non-dialysis and dialysis patients, and healthy controls, to assess alterations in PA during the transition from CKD-5 non-dialysis to dialysis, and to relate PA to BC. Methods: For the cross-sectional analyses 44 CKD-5 non-dialysis patients, 29 dialysis patients, and 20 healthy controls were included. PA was measured by the SenseWear (TM) pro3. Also, the walking speed and handgrip strength (HGS) were measured. BC was measured by the Body Composition Monitor (c). Longitudinally, these parameters were assessed in 42 CKD-5 nondialysis patients (who were also part of the cross-sectional analysis), before the start of dialysis and 6 months thereafter. Results: PA was significantly lower in CKD-5 non-dialysis patients as compared to that in healthy controls but not as compared to that in dialysis patients. HGS was significantly lower in dialysis patients as compared to that in healthy controls. Walking speed was significantly lower in CKD-5 non-dialysis patients as compared to that in healthy controls but not as compared to that in dialysis patients. Six months after starting dialysis, activity related energy expenditure (AEE) and walking speed significantly increased. Conclusions: PA is already lower in CKD-5 non-dialysis patients as compared to that in healthy controls and does not differ from that of dialysis patients. However, the transition phase from CKD-5 non-dialysis to dialysis is associated only with a modest improvement in AEE. (C) 2017 The Author(s) Published by S. Karger AG, Basel

Original languageEnglish
Pages (from-to)47-56
Number of pages10
JournalThe Nephron Journals
Volume137
Issue number1
DOIs
Publication statusPublished - 2017

Keywords

  • Body composition
  • Dialysis
  • End-stage renal disease
  • Physical activity
  • CHRONIC KIDNEY-DISEASE
  • AMBULATORY PERITONEAL-DIALYSIS
  • LOWER-EXTREMITY FUNCTION
  • HEMODIALYSIS-PATIENTS
  • BODY-COMPOSITION
  • MUSCLE STRENGTH
  • SUBSEQUENT DISABILITY
  • INTERNATIONAL COHORT
  • SENSEWEAR ARMBAND
  • OLDER ADULTS

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