Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study

Carlos Celis-Morales, Cyril F. M. Marsaux, Katherine M. Livingstone, Santiago Navas-Carretero, Rodrigo San-Cristobal, Clare B. O'donovan, Hannah Forster, Clara Woolhead, Rosalind Fallaize, Anna L. Macready, Silvia Kolossa, Jacqueline Hallmann, Lydia Tsirigoti, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Keith Grimaldi, Jildau Bouwman, Yannis ManiosIwona Traczyk, Christian A. Drevon, Laurence D. Parnell, Hannelore Daniel, Eileen R. Gibney, Lorraine Brennan, Marianne C. Walsh, Mike Gibney, Julie A. Lovegrove, J. Alfredo Martinez, Wim H. M. Saris, John C. Mathers*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Web of Science)

Abstract

Objective To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P
Original languageEnglish
Pages (from-to)962-969
JournalObesity
Volume24
Issue number4
DOIs
Publication statusPublished - Apr 2016

Cite this