Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study

Carlos Celis-Morales; Cyril F. M. Marsaux; Katherine M. Livingstone; Santiago Navas-Carretero; Rodrigo San-Cristobal; Clare B. O'donovan; Hannah Forster; Clara Woolhead; Rosalind Fallaize; Anna L. Macready; Silvia Kolossa; Jacqueline Hallmann; Lydia Tsirigoti; Christina P. Lambrinou; George Moschonis; Magdalena Godlewska; Agnieszka Surwillo; Keith Grimaldi; Jildau Bouwman; Yannis Manios; Iwona Traczyk; Christian A. Drevon; Laurence D. Parnell; Hannelore Daniel; Eileen R. Gibney; Lorraine Brennan; Marianne C. Walsh; Mike Gibney; Julie A. Lovegrove; J. Alfredo Martinez; Wim H. M. Saris; John C. Mathers

doi:10.1002/oby.21422

Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study

Carlos Celis-Morales, Cyril F. M. Marsaux, Katherine M. Livingstone, Santiago Navas-Carretero, Rodrigo San-Cristobal, Clare B. O'donovan, Hannah Forster, Clara Woolhead, Rosalind Fallaize, Anna L. Macready, Silvia Kolossa, Jacqueline Hallmann, Lydia Tsirigoti, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo, Keith Grimaldi, Jildau Bouwman, Yannis ManiosIwona Traczyk, Christian A. Drevon, Laurence D. Parnell, Hannelore Daniel, Eileen R. Gibney, Lorraine Brennan, Marianne C. Walsh, Mike Gibney, Julie A. Lovegrove, J. Alfredo Martinez, Wim H. M. Saris, John C. Mathers^*

^*Corresponding author for this work

Humane Biologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P

Original language	English
Pages (from-to)	962-969
Journal	Obesity
Volume	24
Issue number	4
DOIs	https://doi.org/10.1002/oby.21422
Publication status	Published - Apr 2016

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Celis-Morales, C., Marsaux, C. F. M., Livingstone, K. M., Navas-Carretero, S., San-Cristobal, R., O'donovan, C. B., Forster, H., Woolhead, C., Fallaize, R., Macready, A. L., Kolossa, S., Hallmann, J., Tsirigoti, L., Lambrinou, C. P., Moschonis, G., Godlewska, M., Surwillo, A., Grimaldi, K., Bouwman, J., ... Mathers, J. C. (2016). Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study. Obesity, 24(4), 962-969. https://doi.org/10.1002/oby.21422

@article{bf3ff1cd4bac485da96ac70e166ff2cf,

title = "Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study",

abstract = "Objective To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P",

author = "Carlos Celis-Morales and Marsaux, {Cyril F. M.} and Livingstone, {Katherine M.} and Santiago Navas-Carretero and Rodrigo San-Cristobal and O'donovan, {Clare B.} and Hannah Forster and Clara Woolhead and Rosalind Fallaize and Macready, {Anna L.} and Silvia Kolossa and Jacqueline Hallmann and Lydia Tsirigoti and Lambrinou, {Christina P.} and George Moschonis and Magdalena Godlewska and Agnieszka Surwillo and Keith Grimaldi and Jildau Bouwman and Yannis Manios and Iwona Traczyk and Drevon, {Christian A.} and Parnell, {Laurence D.} and Hannelore Daniel and Gibney, {Eileen R.} and Lorraine Brennan and Walsh, {Marianne C.} and Mike Gibney and Lovegrove, {Julie A.} and {Alfredo Martinez}, J. and Saris, {Wim H. M.} and Mathers, {John C.}",

year = "2016",

month = apr,

doi = "10.1002/oby.21422",

language = "English",

volume = "24",

pages = "962--969",

journal = "Obesity",

issn = "1930-7381",

publisher = "Wiley",

number = "4",

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Celis-Morales, C, Marsaux, CFM, Livingstone, KM, Navas-Carretero, S, San-Cristobal, R, O'donovan, CB, Forster, H, Woolhead, C, Fallaize, R, Macready, AL, Kolossa, S, Hallmann, J, Tsirigoti, L, Lambrinou, CP, Moschonis, G, Godlewska, M, Surwillo, A, Grimaldi, K, Bouwman, J, Manios, Y, Traczyk, I, Drevon, CA, Parnell, LD, Daniel, H, Gibney, ER, Brennan, L, Walsh, MC, Gibney, M, Lovegrove, JA, Alfredo Martinez, J, Saris, WHM & Mathers, JC 2016, 'Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study', Obesity, vol. 24, no. 4, pp. 962-969. https://doi.org/10.1002/oby.21422

TY - JOUR

T1 - Physical activity attenuates the effect of the FTO genotype on obesity traits in European adults: The Food4Me study

AU - Celis-Morales, Carlos

AU - Marsaux, Cyril F. M.

AU - Livingstone, Katherine M.

AU - Navas-Carretero, Santiago

AU - San-Cristobal, Rodrigo

AU - O'donovan, Clare B.

AU - Forster, Hannah

AU - Woolhead, Clara

AU - Fallaize, Rosalind

AU - Macready, Anna L.

AU - Kolossa, Silvia

AU - Hallmann, Jacqueline

AU - Tsirigoti, Lydia

AU - Lambrinou, Christina P.

AU - Moschonis, George

AU - Godlewska, Magdalena

AU - Surwillo, Agnieszka

AU - Grimaldi, Keith

AU - Bouwman, Jildau

AU - Manios, Yannis

AU - Traczyk, Iwona

AU - Drevon, Christian A.

AU - Parnell, Laurence D.

AU - Daniel, Hannelore

AU - Gibney, Eileen R.

AU - Brennan, Lorraine

AU - Walsh, Marianne C.

AU - Gibney, Mike

AU - Lovegrove, Julie A.

AU - Alfredo Martinez, J.

AU - Saris, Wim H. M.

AU - Mathers, John C.

PY - 2016/4

Y1 - 2016/4

N2 - Objective To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P

AB - Objective To examine whether the effect of FTO loci on obesity-related traits could be modified by physical activity (PA) levels in European adults. MethodsOf 1,607 Food4Me participants randomized, 1,280 were genotyped for FTO (rs9939609) and had available PA data. PA was measured objectively using accelerometers (TracmorD, Philips), whereas anthropometric measures [BMI and waist circumference (WC)] were self-reported via the Internet. ResultsFTO genotype was associated with a higher body weight [: 1.09 kg per risk allele, (95% CI: 0.14-2.04), P=0.024], BMI [: 0.54 kgm(-2), (0.23-0.83), P

U2 - 10.1002/oby.21422

DO - 10.1002/oby.21422

M3 - Article

C2 - 26921105

SN - 1930-7381

VL - 24

SP - 962

EP - 969

JO - Obesity

JF - Obesity

IS - 4

ER -