Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

A. Westers-Attema; B.G.P.M. Lohman; F. van den Heijkant; P.J. Nelemans; V.J. Winnepenninckx; N.W.J. Kelleners-Smeets; K. Mosterd

doi:10.1159/000366500

Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

A. Westers-Attema^*, B.G.P.M. Lohman, F. van den Heijkant, P.J. Nelemans, V.J. Winnepenninckx, N.W.J. Kelleners-Smeets, K. Mosterd

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Background: In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. Objective: This retrospective study examines whether clinical and histological features of BD impact PDT response. Methods: Patients with previously untreated BD from 2002 until 2007 were identified at the Maastricht University Medical Centre. Patients treated with PDT were included. All histological slides were re-examined. Results: During the study period 98 tumours were treated with PDT. In univariate analysis severe atypia and higher age were associated with decreased probability of clinical clearance. Higher age was also associated with an increased risk of recurrence. In multivariate analysis severe atypia remained the only independent risk factor for therapy failure. Conclusion: In patients with BD, severe atypia and higher age are associated with an increased risk of treatment failure after PDT.

Original language	English
Pages (from-to)	55-61
Journal	Dermatology
Volume	230
Issue number	1
DOIs	https://doi.org/10.1159/000366500
Publication status	Published - 1 Jan 2015

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10.1159/000366500

Cite this

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title = "Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success",

abstract = "Background: In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. Objective: This retrospective study examines whether clinical and histological features of BD impact PDT response. Methods: Patients with previously untreated BD from 2002 until 2007 were identified at the Maastricht University Medical Centre. Patients treated with PDT were included. All histological slides were re-examined. Results: During the study period 98 tumours were treated with PDT. In univariate analysis severe atypia and higher age were associated with decreased probability of clinical clearance. Higher age was also associated with an increased risk of recurrence. In multivariate analysis severe atypia remained the only independent risk factor for therapy failure. Conclusion: In patients with BD, severe atypia and higher age are associated with an increased risk of treatment failure after PDT. ",

author = "A. Westers-Attema and B.G.P.M. Lohman and {van den Heijkant}, F. and P.J. Nelemans and V.J. Winnepenninckx and N.W.J. Kelleners-Smeets and K. Mosterd",

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T1 - Photodynamic Therapy in Bowen's Disease: Influence of Histological Features and Clinical Characteristics on Its Success

AU - Westers-Attema, A.

AU - Lohman, B.G.P.M.

AU - van den Heijkant, F.

AU - Nelemans, P.J.

AU - Winnepenninckx, V.J.

AU - Kelleners-Smeets, N.W.J.

AU - Mosterd, K.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Background: In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. Objective: This retrospective study examines whether clinical and histological features of BD impact PDT response. Methods: Patients with previously untreated BD from 2002 until 2007 were identified at the Maastricht University Medical Centre. Patients treated with PDT were included. All histological slides were re-examined. Results: During the study period 98 tumours were treated with PDT. In univariate analysis severe atypia and higher age were associated with decreased probability of clinical clearance. Higher age was also associated with an increased risk of recurrence. In multivariate analysis severe atypia remained the only independent risk factor for therapy failure. Conclusion: In patients with BD, severe atypia and higher age are associated with an increased risk of treatment failure after PDT.

AB - Background: In Bowen's disease (BD) there is no consensus on optimal treatment. Photodynamic therapy (PDT) is an effective non-invasive treatment modality for BD with excellent cosmetic results. Objective: This retrospective study examines whether clinical and histological features of BD impact PDT response. Methods: Patients with previously untreated BD from 2002 until 2007 were identified at the Maastricht University Medical Centre. Patients treated with PDT were included. All histological slides were re-examined. Results: During the study period 98 tumours were treated with PDT. In univariate analysis severe atypia and higher age were associated with decreased probability of clinical clearance. Higher age was also associated with an increased risk of recurrence. In multivariate analysis severe atypia remained the only independent risk factor for therapy failure. Conclusion: In patients with BD, severe atypia and higher age are associated with an increased risk of treatment failure after PDT.

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DO - 10.1159/000366500

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