Phospholipid exchange proteins in synaptosome and myelin fraction from rat brain

K.W.A. Wirtz; J. Jolles; J. Westerman; F. Neys

doi:10.1038/260354a0

Phospholipid exchange proteins in synaptosome and myelin fraction from rat brain

K.W.A. Wirtz, J. Jolles, J. Westerman, F. Neys

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Abstract

ACETYLCHOLINE stimulates the turnover of phosphatidylinositol (PI) and phosphatidic acid (PA) in brain in vitro and in vivo2,3. It has been suggested that this effect on phospholipid metabolism is related to synaptic nerve pulse conductance4,5, and that phospholipid exchange proteins transfer PI from the site of synthesis—the endoplasmic reticulum—to the synaptosomal plasma membrane5. Exchange proteins have been isolated from bovine brain that transfer PI to membranes deficient in this phospholipid in vitro6–8. These proteins also catalyse the transfer of phosphatidylcholine (PC) and PA, although to a lesser extent7. We report here the presence of phospholipid exchange proteins in the soluble protein fractions derived from a synaptosomal membrane and myelin fraction.

Original language	English
Pages (from-to)	354-355
Number of pages	2
Journal	Nature
Volume	260
Issue number	5549
DOIs	https://doi.org/10.1038/260354a0
Publication status	Published - 1 Jan 1976

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title = "Phospholipid exchange proteins in synaptosome and myelin fraction from rat brain",

abstract = "ACETYLCHOLINE stimulates the turnover of phosphatidylinositol (PI) and phosphatidic acid (PA) in brain in vitro and in vivo2,3. It has been suggested that this effect on phospholipid metabolism is related to synaptic nerve pulse conductance4,5, and that phospholipid exchange proteins transfer PI from the site of synthesis—the endoplasmic reticulum—to the synaptosomal plasma membrane5. Exchange proteins have been isolated from bovine brain that transfer PI to membranes deficient in this phospholipid in vitro6–8. These proteins also catalyse the transfer of phosphatidylcholine (PC) and PA, although to a lesser extent7. We report here the presence of phospholipid exchange proteins in the soluble protein fractions derived from a synaptosomal membrane and myelin fraction.",

author = "K.W.A. Wirtz and J. Jolles and J. Westerman and F. Neys",

year = "1976",

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T1 - Phospholipid exchange proteins in synaptosome and myelin fraction from rat brain

AU - Wirtz, K.W.A.

AU - Jolles, J.

AU - Westerman, J.

AU - Neys, F.

PY - 1976/1/1

Y1 - 1976/1/1

N2 - ACETYLCHOLINE stimulates the turnover of phosphatidylinositol (PI) and phosphatidic acid (PA) in brain in vitro and in vivo2,3. It has been suggested that this effect on phospholipid metabolism is related to synaptic nerve pulse conductance4,5, and that phospholipid exchange proteins transfer PI from the site of synthesis—the endoplasmic reticulum—to the synaptosomal plasma membrane5. Exchange proteins have been isolated from bovine brain that transfer PI to membranes deficient in this phospholipid in vitro6–8. These proteins also catalyse the transfer of phosphatidylcholine (PC) and PA, although to a lesser extent7. We report here the presence of phospholipid exchange proteins in the soluble protein fractions derived from a synaptosomal membrane and myelin fraction.

AB - ACETYLCHOLINE stimulates the turnover of phosphatidylinositol (PI) and phosphatidic acid (PA) in brain in vitro and in vivo2,3. It has been suggested that this effect on phospholipid metabolism is related to synaptic nerve pulse conductance4,5, and that phospholipid exchange proteins transfer PI from the site of synthesis—the endoplasmic reticulum—to the synaptosomal plasma membrane5. Exchange proteins have been isolated from bovine brain that transfer PI to membranes deficient in this phospholipid in vitro6–8. These proteins also catalyse the transfer of phosphatidylcholine (PC) and PA, although to a lesser extent7. We report here the presence of phospholipid exchange proteins in the soluble protein fractions derived from a synaptosomal membrane and myelin fraction.

U2 - 10.1038/260354a0

DO - 10.1038/260354a0

M3 - Article

SN - 0028-0836

VL - 260

SP - 354

EP - 355

JO - Nature

JF - Nature

IS - 5549

ER -

Phospholipid exchange proteins in synaptosome and myelin fraction from rat brain

Abstract

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