Abstract
Preclinical studies have shown that phosphodiesterase inhibitors (PDE-Is) represent a potential pharmacological strategy for the treatment of brain ischemia sequelea. PDE-Is 3, 4 and 5 have been tested in several brain ischemia models. All the three PDE-Is after acute or chronic treatment decreased the degree of neurodegeneration and most of them improved functional recovery after brain injury by specific cellular and molecular mechanisms mainly involving an anti-inflammatory and/or neuroprotection action. In contrast to the large number of investigations using PDE-Is in experimental brain ischemia research, the number of clinical studies is still limited. The purpose of this review is to summarize the data currently available on the effects of PDE-Is in experimental models of cerebral ischemia.
Original language | English |
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Pages (from-to) | 1012-1023 |
Journal | Cns & Neurological Disorders-Drug Targets |
Volume | 14 |
Issue number | 8 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Animal models
- brain ischemia
- stroke
- phosphodiesterase inhibitors