Phosphatidylinositol kinase is reduced in Alzheimer's disease

J. Jolles, J. Bothmer, M. Markerink, R. Ravid

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    Abstract

    Abstract: Phosphatidylinositol (PI) kinase and PI phosphate (PIP) kinase activities were measured in postmortem samples of brain tissue from patients with Alzheimer's disease and nondemented control subjects. A membrane‐free cytosolic fraction from four neocortical locations, with exogenous inositol lipids as the substrate, was used. Tissue from patients with Alzheimer's disease was characterized by reduced PIP formation; the reduction was 50% in prefrontal cortex, temporal cortex, and parietal cortex and 40% in precentral gyrus. In contrast, no alterations were found in PI bisphosphate formation in these four neocortical locations. The specific changes in PI kinase but not PIP kinase activity suggest that the findings may have functional relevance to the involvement of brain membrane processes in Alzheimer's disease.
    Original languageEnglish
    Pages (from-to)2326-2329
    Number of pages4
    JournalJournal of Neurochemistry
    Volume58
    Issue number6
    DOIs
    Publication statusPublished - 1 Jan 1992

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