Phenotyping the haemostatic system by thrombography: Potential for the estimation of thrombotic risk

Veronique Regnault; H. Coenraad Hemker; Denis Wahl; Thomas Lecompte

doi:10.1016/j.thromres.2004.06.017

Phenotyping the haemostatic system by thrombography: Potential for the estimation of thrombotic risk

Veronique Regnault^*, H. Coenraad Hemker, Denis Wahl, Thomas Lecompte

^*Corresponding author for this work

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Abstract

The aim of this paper is to review the thrombogram and its use for phenotyping the haemostatic system. The thrombogram can be readily obtained through Calibrated Automated Thrombography (CAT), using a commercially available fluorometer, dedicated software (Thrombinoscope (R)) and a calibrator. Here we explore the possibility to use platelet-rich plasma (PRP) triggered with a low amount of recombinant human tissue factor (similar to 0.5 pM) and also explore the function of the protein C system by adding activated protein C (APC) or soluble recombinant thrombomodulin (TM). Examples are shown: inherited antithrombin (AT) and protein C deficiencies, and antiphospholipid antibodies. (c) 2004 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	539-545
Number of pages	7
Journal	Thrombosis Research
Volume	114
Issue number	5-6
DOIs	https://doi.org/10.1016/j.thromres.2004.06.017
Publication status	Published - 2004

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title = "Phenotyping the haemostatic system by thrombography: Potential for the estimation of thrombotic risk",

abstract = "The aim of this paper is to review the thrombogram and its use for phenotyping the haemostatic system. The thrombogram can be readily obtained through Calibrated Automated Thrombography (CAT), using a commercially available fluorometer, dedicated software (Thrombinoscope (R)) and a calibrator. Here we explore the possibility to use platelet-rich plasma (PRP) triggered with a low amount of recombinant human tissue factor (similar to 0.5 pM) and also explore the function of the protein C system by adding activated protein C (APC) or soluble recombinant thrombomodulin (TM). Examples are shown: inherited antithrombin (AT) and protein C deficiencies, and antiphospholipid antibodies. (c) 2004 Elsevier Ltd. All rights reserved.",

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AU - Regnault, Veronique

AU - Hemker, H. Coenraad

AU - Wahl, Denis

AU - Lecompte, Thomas

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AB - The aim of this paper is to review the thrombogram and its use for phenotyping the haemostatic system. The thrombogram can be readily obtained through Calibrated Automated Thrombography (CAT), using a commercially available fluorometer, dedicated software (Thrombinoscope (R)) and a calibrator. Here we explore the possibility to use platelet-rich plasma (PRP) triggered with a low amount of recombinant human tissue factor (similar to 0.5 pM) and also explore the function of the protein C system by adding activated protein C (APC) or soluble recombinant thrombomodulin (TM). Examples are shown: inherited antithrombin (AT) and protein C deficiencies, and antiphospholipid antibodies. (c) 2004 Elsevier Ltd. All rights reserved.

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DO - 10.1016/j.thromres.2004.06.017

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JO - Thrombosis Research

JF - Thrombosis Research

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