Phenotype at diagnosis predicts recurrence rates in Crohn's disease.

F. Wolters*, M.G.V. Russel, J. Sijbrandij, T. Ambergen, S. Odes, L. Riis, E. Langholz, P. Politi, A. Qasim, I. Koutroubakis, E. Tsianos, S. Vermeire, J. Freitas, G. van Zeijl, O. Hoie, T. Bernklev, M. Beltrami, D. Rodriguez, R.W. Stockbrugger, B. Moum

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


AB - BACKGROUND: In Crohn's disease (CD), studies associating phenotype at diagnosis and subsequent disease activity are important for patient counselling and health care planning. AIMS: To calculate disease recurrence rates and to correlate these with phenotypic traits at diagnosis. METHODS: A prospectively assembled uniformly diagnosed European population-based inception cohort of CD patients was classified according to the Vienna Classification for disease phenotype at diagnosis. Surgical and non-surgical recurrence rates throughout a ten-year follow-up period were calculated. Multivariate analysis was performed to classify risk factors present at diagnosis for recurrent disease. RESULTS: A total of 358 were classified for phenotype at diagnosis of whom 262 (73.2%) had a first recurrence and 113 patients (31.6%) a first surgical recurrence during the first 10 years after diagnosis. Patients with upper gastrointestinal disease at diagnosis had excess risk of recurrences (Hazard Ratio (HR): 1.54, 95% Confidence Interval (CI): 1.13 - 2.10) whereas age >/=40 years at diagnosis was protective (HR: 0.82, 95% CI: 0.70 - 0.97). Colonic disease was a protective characteristic for resective surgery (HR: 0.38, 95% CI: 0.21 - 0.69). More frequent resective surgical recurrences were reported from Copenhagen (HR: 3.23, 95% CI: 1.32 - 7.89). CONCLUSIONS: A mild course of disease in terms of disease recurrence was observed in this European cohort. Phenotype at diagnosis had predictive value for disease recurrence with upper gastro-intestinal disease being the most important positive predictor. A phenotypic North- South gradient in CD may be present illustrated by higher surgery risks in some of the Northern-European centres
Original languageEnglish
Pages (from-to)1124-1130
Issue number8
Publication statusPublished - 1 Jan 2006

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