Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis

Erika M. Palmieri, Alessio Menga, Rosa Martin-Perez, Annamaria Quinto, Carla Riera-Domingo, Giacoma De Tullio, Douglas C. Hooper, Wouter H. Lamers, Bart Ghesquiere, Daniel W. McVicar, Attilio Guarini, Massimiliano Mazzone, Alessandra Castegna

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Pages (from-to)1654-1666
Number of pages13
JournalCell Reports
Volume20
Issue number7
DOIs
Publication statusPublished - 15 Aug 2017

Keywords

  • INNATE IMMUNITY
  • CELL MIGRATION
  • METABOLISM
  • POLARIZATION
  • EXPRESSION
  • INFLAMMATION
  • ACTIVATION
  • CANCER
  • DEFICIENCY
  • PLASTICITY

Cite this

Palmieri, E. M., Menga, A., Martin-Perez, R., Quinto, A., Riera-Domingo, C., De Tullio, G., Hooper, D. C., Lamers, W. H., Ghesquiere, B., McVicar, D. W., Guarini, A., Mazzone, M., & Castegna, A. (2017). Pharmacologic or Genetic Targeting of Glutamine Synthetase Skews Macrophages toward an M1-like Phenotype and Inhibits Tumor Metastasis. Cell Reports, 20(7), 1654-1666. https://doi.org/10.1016/j.celrep.2017.07.054