Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study

Nicole M. L. Veldhorst-Janssen; Audrey A. A. Fiddelers; Paul-Hugo M. van der Kuy; H. Maurice S. Theunissen; Marc C. T. F. M. de Krom; Cees Neef; Marco A. E. Marcus

doi:10.1016/j.clinthera.2011.10.012

Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study

Nicole M. L. Veldhorst-Janssen, Audrey A. A. Fiddelers, Paul-Hugo M. van der Kuy, H. Maurice S. Theunissen, Marc C. T. F. M. de Krom, Cees Neef, Marco A. E. Marcus

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	2022-2028
Journal	Clinical Therapeutics
Volume	33
Issue number	12
DOIs	https://doi.org/10.1016/j.clinthera.2011.10.012
Publication status	Published - Dec 2011

Keywords

intranasal
midazolam
pharmacokinetics
pilot study

Access to Document

10.1016/j.clinthera.2011.10.012

Cite this

Veldhorst-Janssen, N. M. L., Fiddelers, A. A. A., van der Kuy, P-H. M., Theunissen, H. M. S., de Krom, M. C. T. F. M., Neef, C., & Marcus, M. A. E. (2011). Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study. Clinical Therapeutics, 33(12), 2022-2028. https://doi.org/10.1016/j.clinthera.2011.10.012

Veldhorst-Janssen, Nicole M. L. ; Fiddelers, Audrey A. A. ; van der Kuy, Paul-Hugo M. ; Theunissen, H. Maurice S. ; de Krom, Marc C. T. F. M. ; Neef, Cees ; Marcus, Marco A. E. / Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study. In: Clinical Therapeutics. 2011 ; Vol. 33, No. 12. pp. 2022-2028.

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title = "Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study",

keywords = "intranasal, midazolam, pharmacokinetics, pilot study",

author = "Veldhorst-Janssen, {Nicole M. L.} and Fiddelers, {Audrey A. A.} and {van der Kuy}, {Paul-Hugo M.} and Theunissen, {H. Maurice S.} and {de Krom}, {Marc C. T. F. M.} and Cees Neef and Marcus, {Marco A. E.}",

year = "2011",

month = dec,

doi = "10.1016/j.clinthera.2011.10.012",

language = "English",

volume = "33",

pages = "2022--2028",

journal = "Clinical Therapeutics",

issn = "0149-2918",

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Veldhorst-Janssen, NML, Fiddelers, AAA, van der Kuy, P-HM, Theunissen, HMS, de Krom, MCTFM, Neef, C & Marcus, MAE 2011, 'Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study', Clinical Therapeutics, vol. 33, no. 12, pp. 2022-2028. https://doi.org/10.1016/j.clinthera.2011.10.012

Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study. / Veldhorst-Janssen, Nicole M. L.; Fiddelers, Audrey A. A.; van der Kuy, Paul-Hugo M.; Theunissen, H. Maurice S.; de Krom, Marc C. T. F. M.; Neef, Cees; Marcus, Marco A. E.

In: Clinical Therapeutics, Vol. 33, No. 12, 12.2011, p. 2022-2028.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study

AU - Veldhorst-Janssen, Nicole M. L.

AU - Fiddelers, Audrey A. A.

AU - van der Kuy, Paul-Hugo M.

AU - Theunissen, H. Maurice S.

AU - de Krom, Marc C. T. F. M.

AU - Neef, Cees

AU - Marcus, Marco A. E.

PY - 2011/12

Y1 - 2011/12

KW - intranasal

KW - midazolam

KW - pharmacokinetics

KW - pilot study

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DO - 10.1016/j.clinthera.2011.10.012

M3 - Article

VL - 33

SP - 2022

EP - 2028

JO - Clinical Therapeutics

JF - Clinical Therapeutics

SN - 0149-2918

IS - 12

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Veldhorst-Janssen NML, Fiddelers AAA, van der Kuy P-HM, Theunissen HMS, de Krom MCTFM, Neef C et al. Pharmacokinetics and Tolerability of Nasal Versus Intravenous Midazolam in Healthy Dutch Volunteers: A Single-Dose, Randomized-Sequence, Open-Label, 2-Period Crossover Pilot Study. Clinical Therapeutics. 2011 Dec;33(12):2022-2028. https://doi.org/10.1016/j.clinthera.2011.10.012