Abstract
Patients with inflammatory bowel disease (IBD) show large variability in disease course, and also treatment response. The variability in treatment response has led to many initiatives in search of genetic markers to optimize treatment and avoid severe side effects. This has been very successful for thiopurines, one of the drugs used to induce and maintain remission in IBD. However, for the newer treatment options for IBD, like biologicals, the search for genetic predictors has not yielded any candidate biomarkers with clinical utility. In this review, a summary of recent advances in pharmacogenetics focusing on thiopurines and anti-TNF agents is given.
Tweetable abstract
In this paper, recent advances in pharmacogenetics in inflammatory bowel disease are discussed, focusing on thiopurines and anti-TNF agents.
| Original language | English |
|---|---|
| Pages (from-to) | 55-66 |
| Number of pages | 12 |
| Journal | Pharmacogenomics |
| Volume | 22 |
| Issue number | 1 |
| Early online date | 11 Dec 2020 |
| DOIs | |
| Publication status | Published - Jan 2021 |
Keywords
- adverse drug reactions
- antitumor necrosis factor treatment
- genome-wide association study
- HLA
- inflammatory bowel disease
- pharmacogenetics
- TPMT gene
- thiopurines
- INOSINE TRIPHOSPHATE PYROPHOSPHATASE
- GENOME-WIDE ASSOCIATION
- CROHNS-DISEASE
- THIOPURINE METHYLTRANSFERASE
- FECAL CALPROTECTIN
- FOLLOW-UP
- DIFFERENTIAL RESPONSE
- GENETIC-POLYMORPHISM
- ULCERATIVE-COLITIS
- CLINICAL-RESPONSE