Personalized Medicine: Review and Perspectives of Promising Baseline EEG Biomarkers in Major Depressive Disorder and Attention Deficit Hyperactivity Disorder

Sebastian Olbrich*, Rik van Dinteren, Martijn Arns

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

59 Citations (Web of Science)

Abstract

Personalized medicine in psychiatry is in need of biomarkers that resemble central nervous system function at the level of neuronal activity. Electroencephalography (EEG) during sleep or resting-state conditions and event-related potentials (ERPs) have not only been used to discriminate patients from healthy subjects, but also for the prediction of treatment outcome in various psychiatric diseases, yielding information about tailored therapy approaches for an individual. This review focuses on baseline EEG markers for two psychiatric conditions, namely major depressive disorder and attention deficit hyperactivity disorder. It covers potential biomarkers from EEG sleep research and vigilance regulation, paroxysmal EEG patterns and epileptiform discharges, quantitative EEG features within the EEG main frequency bands, connectivity markers and ERP components that might help to identify favourable treatment outcome. Further, the various markers are discussed in the context of their potential clinical value and as research domain criteria, before giving an outline for future studies that are needed to pave the way to an electrophysiological biomarker-based personalized medicine. (C) 2016 S. Karger AG, Basel

Original languageEnglish
Pages (from-to)229-240
Number of pages12
JournalNeuropsychobiology
Volume72
Issue number3-4
DOIs
Publication statusPublished - 2015
Externally publishedYes

Keywords

  • Quantitative electroencephalography
  • Depression
  • Attention deficit hyperactivity disorder
  • Event-related potentials
  • Personalized medicine
  • Biomarker
  • Research domain criteria
  • EVENT-RELATED POTENTIALS
  • ELECTROENCEPHALOGRAPHIC SLEEP PROFILES
  • CENTRAL SEROTONERGIC NEUROTRANSMISSION
  • TRANSCRANIAL MAGNETIC STIMULATION
  • BRAIN ELECTRICAL TOMOGRAPHY
  • PREDICTS TREATMENT RESPONSE
  • AUDITORY-EVOKED-POTENTIALS
  • PROLONGED P300 LATENCY
  • SURROGATE END-POINTS
  • SLOW-WAVE ACTIVITY

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