Personalization of Biomechanical Models for Early Detection of Disease in Arrhythmogenic Cardiomyopathy

N. van Osta*, A. Lyon, T. Koopsen, T. Delhaas, J. Lumens, F. Kirkels, M.J. Cramer, A.J. Teske

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingConference article in proceedingAcademicpeer-review

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Abstract

Arrhythmogenic cardiomyopathy (AC) is an inherited cardiac disease clinically characterized by life-threatening ventricular arrhythmias and progressive cardiac dysfunction. Current electrocardiographic and structural imaging methods fail to detect early-stage AC-related myocardial disease in mutation carriers. Here, we propose a cardiac imaging-based personalized modelling approach that enables the identification and characterization of regional electro-mechanical tissue abnormalities in the vulnerable right ventricular (RV) free wall of AC mutation carriers.RV tissue deformation data from 2 controls and 8 mutation carriers, covering various stages of AC disease, were used to personalize the CircAdapt model of the human heart and circulation. This resulted in estimates of contractility and stiffness in the apical, midventricular, and basal segments of the RV.Apex-to-base heterogeneity in tissue properties, with increased stiffness and decreased contractility in the RV basal region, was found in most patients and was largest in late-stage AC disease. Future studies should evaluate whether early-stage tissue heterogeneity is predictive for arrhythmic events or AC disease progression.
Original languageEnglish
Title of host publicationComputing in Cardiology Conference, CinC 2018
PublisherIEEE
Number of pages4
Volume45
ISBN (Electronic)9781728109589
ISBN (Print)9781728109589
DOIs
Publication statusPublished - Sept 2018
Event45th Computing in Cardiology Conference (CinC) - NETHERLANDS
Duration: 23 Sept 201826 Sept 2018

Publication series

SeriesComputing in Cardiology Conference
Volume45
ISSN2325-8861

Conference

Conference45th Computing in Cardiology Conference (CinC)
Period23/09/1826/09/18

Keywords

  • RIGHT-VENTRICULAR DYSPLASIA/CARDIOMYOPATHY

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