TY - JOUR
T1 - Personal assessment of the external exposome during pregnancy and childhood in Europe
AU - Donaire-Gonzalez, David
AU - Curto, Ariadna
AU - Valentin, Antonia
AU - Andrusaityte, Sandra
AU - Basagana, Xavier
AU - Casas, Maribel
AU - Chatzi, Leda
AU - de Bont, Jeroen
AU - de Castro, Montserrat
AU - Dedele, Audrius
AU - Granum, Berit
AU - Grazuleviciene, Regina
AU - Kampouri, Mariza
AU - Lyon-Caen, Sarah
AU - Manzano-Salgado, Cyntia B.
AU - Aasvang, Gunn Marit
AU - McEachan, Rosemary
AU - Meinhard-Kjellstad, Carin Helena
AU - Michalaki, Eirini
AU - Panella, Pau
AU - Petraviciene, Inga
AU - Schwarze, Per E.
AU - Slama, Remy
AU - Robinson, Oliver
AU - Tamayo-Uria, Ibon
AU - Vafeiadi, Marina
AU - Waiblinger, Dagmar
AU - Wright, John
AU - Vrijheid, Martine
AU - Nieuwenhuijsen, Mark J.
N1 - Funding Information:
The study was funded by the EC grant HELIX ( FP7-ENV-2012-308333 ). The authors acknowledge the EXPOsOMICS project to allow us the use of the prototype of the ExpoApp application, which has been developed as combined effort of the EXPOsOMICS project ( FP7-ENV-2012-308610 ) and HELIX. Cyntia Manzano received funding from Instituto de Salud Carlos III ( Ministry of Economy and Competitiveness ) ( FI14/00099 ). Dr Maribel Casas received funding from Instituto de Salud Carlos III ( Ministry of Economy and Competitiveness ) ( MS16/00128 ). Dr. Regina Grazuleviciene received the grant of the Lithuanian Agency for Science Innovation and Technology (No. 45 31V-66 ). We would like to especially thank Ateknea Solutions for the adaptations and technical support given with the deployment and data extraction from the ExpoApp application utilized to assess the mobility, physical activity and exposure of participants. We also thank all participants of the HELIX study as well as the study teams who made the research possible.
Publisher Copyright:
© 2019 Elsevier Inc.
PY - 2019/7
Y1 - 2019/7
N2 - The human exposome affects child development and health later in life, but its personal external levels, variability, and correlations are largely unknown. We characterized the personal external exposome of pregnant women and children in eight European cities. Panel studies included 167 pregnant women and 183 children (aged 6-11 years). A personal exposure monitoring kit composed of smartphone, accelerometer, ultraviolet (UV) dosimeter, and two air pollution monitors were used to monitor physical activity (PA), fine particulate matter (PM2.5), black carbon, traffic-related noise, UV-B radiation, and natural outdoor environments (NOE). 77% of women performed the adult recommendation of >= 150 min/week of moderate to vigorous PA (MVPA), while only 3% of children achieved the childhood recommendation of >= 60 min/day MVPA. 11% of women and 17% of children were exposed to daily PM2.5 levels higher than recommended >= 25 mu g/m(3)). Mean exposure to noise ranged from Lden 51.1 dB in Kaunas to Lden 65.2 dB in Barcelona. 4% of women and 23% of children exceeded the recommended maximum of 2 Standard-Erythemal-Dose of UV-B at least once a week. 33% of women and 43% of children never reached the minimum NOE contact recommendation of >= 30 min/week. The variations in air and noise pollution exposure were dominated by between-city variability, while most of the variation observed for NOE contact and PA was between-participants. The correlations between all personal exposures ranged from very low to low (Rho <0.30). The levels of personal external exposures in both pregnant women and children are above the health recommendations, and there is little correlation between the different exposures. The assessment of the personal external exposome is feasible but sampling requires from one day to more than one year depending on exposure due to high variability between and within cities and participants.
AB - The human exposome affects child development and health later in life, but its personal external levels, variability, and correlations are largely unknown. We characterized the personal external exposome of pregnant women and children in eight European cities. Panel studies included 167 pregnant women and 183 children (aged 6-11 years). A personal exposure monitoring kit composed of smartphone, accelerometer, ultraviolet (UV) dosimeter, and two air pollution monitors were used to monitor physical activity (PA), fine particulate matter (PM2.5), black carbon, traffic-related noise, UV-B radiation, and natural outdoor environments (NOE). 77% of women performed the adult recommendation of >= 150 min/week of moderate to vigorous PA (MVPA), while only 3% of children achieved the childhood recommendation of >= 60 min/day MVPA. 11% of women and 17% of children were exposed to daily PM2.5 levels higher than recommended >= 25 mu g/m(3)). Mean exposure to noise ranged from Lden 51.1 dB in Kaunas to Lden 65.2 dB in Barcelona. 4% of women and 23% of children exceeded the recommended maximum of 2 Standard-Erythemal-Dose of UV-B at least once a week. 33% of women and 43% of children never reached the minimum NOE contact recommendation of >= 30 min/week. The variations in air and noise pollution exposure were dominated by between-city variability, while most of the variation observed for NOE contact and PA was between-participants. The correlations between all personal exposures ranged from very low to low (Rho <0.30). The levels of personal external exposures in both pregnant women and children are above the health recommendations, and there is little correlation between the different exposures. The assessment of the personal external exposome is feasible but sampling requires from one day to more than one year depending on exposure due to high variability between and within cities and participants.
KW - Personal exposure monitoring
KW - Dynamic modelling
KW - Particulate matter
KW - Black carbon
KW - Physical activity
KW - Green spaces
KW - Ultraviolet radiation
KW - Pregnancy
KW - Childhood
KW - MEASURED PHYSICAL-ACTIVITY
KW - AIR-POLLUTION
KW - BLACK CARBON
KW - ENVIRONMENTAL EXPOSURE
KW - PARTICULATE MATTER
KW - ULTRAVIOLET-RADIATION
KW - SURROUNDING GREENNESS
KW - ULTRAFINE PARTICLES
KW - PATTERNS
KW - HEALTH
U2 - 10.1016/j.envres.2019.04.015
DO - 10.1016/j.envres.2019.04.015
M3 - Article
C2 - 31055170
SN - 0013-9351
VL - 174
SP - 95
EP - 104
JO - Environmental Research
JF - Environmental Research
ER -