PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

Kasper M. Rouschop; Ludwig J. Dubois; Tom G. Keulers; Twan van den Beucken; Philippe Lambin; Johan Bussink; Albert J. van der Kogel; Marianne Koritzinsky; Bradly G. Wouters

doi:10.1073/pnas.1210633110

PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

Kasper M. Rouschop^*, Ludwig J. Dubois, Tom G. Keulers, Twan van den Beucken, Philippe Lambin, Johan Bussink, Albert J. van der Kogel, Marianne Koritzinsky, Bradly G. Wouters

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Original language	English
Pages (from-to)	4622-4627
Journal	Proceedings of the National Academy of Sciences of the United States of America
Volume	110
Issue number	12
DOIs	https://doi.org/10.1073/pnas.1210633110
Publication status	Published - 19 Mar 2013

Keywords

growth delay
irradiation
acute hypoxia

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10.1073/pnas.1210633110

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Cite this

Rouschop, K. M., Dubois, L. J., Keulers, T. G., van den Beucken, T., Lambin, P., Bussink, J., van der Kogel, A. J., Koritzinsky, M., & Wouters, B. G. (2013). PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. Proceedings of the National Academy of Sciences of the United States of America, 110(12), 4622-4627. https://doi.org/10.1073/pnas.1210633110

Rouschop, Kasper M. ; Dubois, Ludwig J. ; Keulers, Tom G. ; van den Beucken, Twan ; Lambin, Philippe ; Bussink, Johan ; van der Kogel, Albert J. ; Koritzinsky, Marianne ; Wouters, Bradly G. / PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. In: Proceedings of the National Academy of Sciences of the United States of America. 2013 ; Vol. 110, No. 12. pp. 4622-4627.

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title = "PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS",

keywords = "growth delay, irradiation, acute hypoxia",

author = "Rouschop, {Kasper M.} and Dubois, {Ludwig J.} and Keulers, {Tom G.} and {van den Beucken}, Twan and Philippe Lambin and Johan Bussink and {van der Kogel}, {Albert J.} and Marianne Koritzinsky and Wouters, {Bradly G.}",

year = "2013",

month = mar,

day = "19",

doi = "10.1073/pnas.1210633110",

language = "English",

volume = "110",

pages = "4622--4627",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "National Academy of Sciences",

number = "12",

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Rouschop, KM , Dubois, LJ , Keulers, TG , van den Beucken, T , Lambin, P, Bussink, J, van der Kogel, AJ, Koritzinsky, M & Wouters, BG 2013, 'PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS', Proceedings of the National Academy of Sciences of the United States of America, vol. 110, no. 12, pp. 4622-4627. https://doi.org/10.1073/pnas.1210633110

PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. / Rouschop, Kasper M.; Dubois, Ludwig J.; Keulers, Tom G.; van den Beucken, Twan ; Lambin, Philippe; Bussink, Johan; van der Kogel, Albert J.; Koritzinsky, Marianne; Wouters, Bradly G.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, No. 12, 19.03.2013, p. 4622-4627.

Research output: Contribution to journal › Article › Academic › peer-review

TY - JOUR

T1 - PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS

AU - Rouschop, Kasper M.

AU - Dubois, Ludwig J.

AU - Keulers, Tom G.

AU - van den Beucken, Twan

AU - Lambin, Philippe

AU - Bussink, Johan

AU - van der Kogel, Albert J.

AU - Koritzinsky, Marianne

AU - Wouters, Bradly G.

PY - 2013/3/19

Y1 - 2013/3/19

KW - growth delay

KW - irradiation

KW - acute hypoxia

U2 - 10.1073/pnas.1210633110

DO - 10.1073/pnas.1210633110

M3 - Article

C2 - 23471998

VL - 110

SP - 4622

EP - 4627

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 12

ER -

Rouschop KM , Dubois LJ , Keulers TG , van den Beucken T , Lambin P, Bussink J et al. PERK/eIF2 alpha signaling protects therapy resistant hypoxic cells through induction of glutathione synthesis and protection against ROS. Proceedings of the National Academy of Sciences of the United States of America. 2013 Mar 19;110(12):4622-4627. https://doi.org/10.1073/pnas.1210633110