TY - JOUR
T1 - Peripheral Artery Disease and Its Clinical Relevance in Patients with Chronic Obstructive Pulmonary Disease in the COPD and Systemic Consequences-Comorbidities Network Study
AU - Houben-Wilkes, Sarah
AU - Joerres, Rudolf A.
AU - Bals, Robert
AU - Franssen, Frits M. E.
AU - Glaeser, Sven
AU - Holle, Rolf
AU - Karch, Annika
AU - Koch, Armin
AU - Magnussen, Helgo
AU - Obst, Anne
AU - Schulz, Holger
AU - Spruit, Martijn A.
AU - Wacker, Margarethe E.
AU - Welte, Tobias
AU - Wouters, Emiel F. M.
AU - Vogelmeier, Claus
AU - Watz, Henrik
PY - 2017/1/15
Y1 - 2017/1/15
N2 - Rationale: Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce.Objectives: We aimed to: (1) assess the prevalence of PAD in COPD compared with distinct control groups; and (2) study the association between PAD and functional capacity as well as health status.Methods: The ankle-brachial index was used to diagnose PAD (ankle-brachial indexMeasurements and Main Results: A total of 2,088 patients with COPD (61.1% male; mean [SD] age, 65.3 [8.2] years, GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV: 9.4, 42.5, 37.5, and 10.5%, respectively) were included, of which 184 patients (8.8%; GOLD stage I-IV: 5.1, 7.4, 11.1, and 9.5%, respectively, vs. 5.9% in patients with GOLD stage 0 in the COPD and Systemic Consequences-Comorbidities Network) had PAD. In the Study of Health in Pomerania, PAD ranged from 1.8 to 4.2%. Patients with COPD with PAD had a significantly shorter 6-minute-walk distance (356 [108] vs. 422 [103] m, P <0.001) and worse health status (St. George's Respiratory Questionnaire: 49.7 [20.1] vs. 42.7 [20.0] points, P <0.001; COPD Assessment Test: 19.6 [7.4] vs. 17.9 [7.4] points, P = 0.004; EuroQol-5-Dimensions visual analog scale: 51.2 [19.0] vs. 57.2 [19.6], P <0.001). Differences remained significant after correction for several confounders.Conclusions: In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.
AB - Rationale: Knowledge about the prevalence of objectively assessed peripheral artery disease (PAD) and its clinical relevance in patients with chronic obstructive pulmonary disease (COPD) is scarce.Objectives: We aimed to: (1) assess the prevalence of PAD in COPD compared with distinct control groups; and (2) study the association between PAD and functional capacity as well as health status.Methods: The ankle-brachial index was used to diagnose PAD (ankle-brachial indexMeasurements and Main Results: A total of 2,088 patients with COPD (61.1% male; mean [SD] age, 65.3 [8.2] years, GOLD (Global Initiative for Chronic Obstructive Lung Disease) stages I-IV: 9.4, 42.5, 37.5, and 10.5%, respectively) were included, of which 184 patients (8.8%; GOLD stage I-IV: 5.1, 7.4, 11.1, and 9.5%, respectively, vs. 5.9% in patients with GOLD stage 0 in the COPD and Systemic Consequences-Comorbidities Network) had PAD. In the Study of Health in Pomerania, PAD ranged from 1.8 to 4.2%. Patients with COPD with PAD had a significantly shorter 6-minute-walk distance (356 [108] vs. 422 [103] m, P <0.001) and worse health status (St. George's Respiratory Questionnaire: 49.7 [20.1] vs. 42.7 [20.0] points, P <0.001; COPD Assessment Test: 19.6 [7.4] vs. 17.9 [7.4] points, P = 0.004; EuroQol-5-Dimensions visual analog scale: 51.2 [19.0] vs. 57.2 [19.6], P <0.001). Differences remained significant after correction for several confounders.Conclusions: In a large cohort of patients with COPD, 8.8% were diagnosed with PAD, which is higher than the prevalence in control subjects without COPD. PAD was associated with a clinically relevant reduction in functional capacity and health status.
KW - chronic obstructive pulmonary disease
KW - comorbidities
KW - peripheral vascular disease
KW - health status
KW - functional capacity
KW - QUALITY-OF-LIFE
KW - MINIMALLY IMPORTANT DIFFERENCES
KW - ANKLE-BRACHIAL INDEX
KW - HEALTH-STATUS
KW - IMPORTANT DIFFERENCE
KW - FUNCTIONAL-CAPACITY
KW - PHYSICAL-ACTIVITY
KW - MORTALITY
KW - COSYCONET
KW - EQ-5D
U2 - 10.1164/rccm.201602-0354OC
DO - 10.1164/rccm.201602-0354OC
M3 - Article
C2 - 27532739
SN - 1073-449X
VL - 195
SP - 189
EP - 197
JO - American Journal of Respiratory and Critical Care Medicine
JF - American Journal of Respiratory and Critical Care Medicine
IS - 2
ER -